Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis

被引：80

作者：

Hessami, Amirhossein ^{[1
,2
,3
]}

Shamshirian, Amir ^{[4
,5
]}

Heydari, Keyvan ^{[1
,4
]}

Pourali, Fatemeh ^{[1
]}

Alizadeh-Navaei, Reza ^{[4
]}

Moosazadeh, Mahmood ^{[4
,6
]}

Abrotan, Saeed ^{[7
]}

Shojaie, Layla ^{[8
]}

Sedighi, Sogol ^{[9
]}

Shamshirian, Danial ^{[10
]}

Rezaei, Nima ^{[3
,11
,12
]}

机构：

[1] Mazandaran Univ Med Sci, Sch Med, Student Res Comm, Sari, Iran

[2] Universal Sci Educ & Res Network USERN, Systemat Review & Meta Anal Expert Grp SRMEG, Tehran, Iran

[3] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran, Iran

[4] Mazandaran Univ Med Sci, Gastrointestinal Canc Res Ctr, Noncommunicable Dis Inst, Sari, Iran

[5] Mazandaran Univ Med Sci, Sch Allied Med Sci, Dept Med Lab Sci, Sari, Iran

[6] Mazandaran Univ Med Sci, Hlth Sci Res Ctr, Addict Inst, Sari, Iran

[7] Babol Univ Med Sci, Dept Cardiol, Babol, Iran

[8] Univ Southern Calif, Res Ctr Liver Dis, Keck Sch Med, Dept Med, Los Angeles, CA 90007 USA

[9] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[10] Shahid Beheshti Univ Med Sci, Chron Resp Dis Res Ctr, Natl Res Inst TB & Lung Dis NRITLD, Tehran, Iran

[11] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

[12] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 2021年 / 46卷

关键词：

COVID-19; Cardiovascular disease; Meta-analysis; RESPIRATORY SYNDROME CORONAVIRUS; CLINICAL CHARACTERISTICS; SARS-COV-2; INFECTION; MYOCARDIAL INJURY; CHEST CT; D-DIMER; PNEUMONIA; WUHAN; OUTCOMES; COMORBIDITIES;

D O I：

10.1016/j.ajem.2020.10.022

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: High rate of cardiovascular disease (CVD) have been reported among patients with novel coronavirus disease (COVID-19). Meanwhile there were controversies among different studies about CVD burden in COVID-19 patients. Hence, we aimed to study CVD burden among COVID-19 patients, using a systematic review and meta-analysis. Methods: We have systematically searched databases including PubMed, Embase, Cochrane Library, Scopus, Web of Science as well as medRxiv pre-print database. Hand searched was also conducted in journal websites and Google Scholar. Meta-analyses were carried out for Odds Ratio (OR) of mortality and Intensive Care Unit (ICU) admission for different CVDs. We have also performed a descriptive meta-analysis on different CVDs. Results: Fifty-six studies entered into meta-analysis for ICU admission and mortality outcome and 198 papers for descriptive outcomes, including 159,698 COVID-19 patients. Results of meta-analysis indicated that acute cardiac injury, (OR: 13.29, 95% CI 7.35-24.03), hypertension (OR: 2.60, 95% CI 2.11-3.19), heart Failure (OR: 6.72, 95% CI 3.34-13.52), arrhythmia (OR: 2.75, 95% CI 1.43-5.25), coronary artery disease (OR: 3.78, 95% CI 2.42-5.90), and cardiovascular disease (OR: 2.61, 95% CI 1.89-3.62) were significantly associated with mortality. Arrhythmia (OR: 7.03, 95% CI 2.79-17.69), acute cardiac injury (OR: 15.58, 95% CI 5.15-47.12), coronary heart disease (OR: 2.61, 95% CI 1.09-6.26), cardiovascular disease (OR: 3.11, 95% CI 1.59-6.09), and hypertension (OR: 1.95, 95% CI 1.41-2.68) were also significantly associated with ICU admission in COVID-19 patients. Conclusion: Findings of this study revealed a high burden of CVDs among COVID-19 patients, which was signifi-cantly associated with mortality and ICU admission. Proper management of CVD patients with COVID-19 and monitoring COVID-19 patients for acute cardiac conditions is highly recommended to prevent mortality and critical situations. (c) 2020 Elsevier Inc. All rights reserved.

引用

页码：382 / 391

页数：10

共 243 条

[1] The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease Insights From Cardiovascular Aging Science [J].