Abnormal Functional Connectivity of the Amygdala-Based Network in Resting-State fMRI in Adolescents with Generalized Anxiety Disorder

被引：0

作者：

Liu, Wen-jing ^{[1
]}

Yin, Da-zhi ^{[2
]}

Cheng, Wen-hong ^{[1
,3
]}

Fan, Ming-xia ^{[2
]}

You, Mei-na ^{[1
]}

Men, Wei-wei ^{[2
]}

Zang, Li-li ^{[2
]}

Shi, Dian-hong ^{[1
]}

Zhang, Fang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Dept Child & Adolescent Psychiat, Shanghai 200030, Peoples R China

[2] E China Normal Univ, Dept Phys, Shanghai Key Lab Magnet Resonance, Shanghai 200062, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Med Psychol, Shanghai 200030, Peoples R China

来源：

MEDICAL SCIENCE MONITOR | 2015年 / 21卷

关键词：

Adolescent; Amygdala; Anxiety Disorders; CEREBELLUM; FEAR; ACTIVATION; CORTEX; STRIATUM; CHILDREN; EMOTION; BRAIN;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: We aimed to investigate the disruptions of functional connectivity of amygdala-based networks in adolescents with untreated generalized anxiety disorder (GAD). Material/Methods: A total of 26 adolescents with first-episode GAD and 20 normal age-matched volunteers underwent resting-state and T1 functional magnetic resonance imaging (fMRI). We analyzed the correlation of fMRI signal fluctuation between the amygdala and other brain regions. The variation of amygdala-based functional connectivity and its correlation with anxiety severity were investigated. Results: Decreased functional connectivity was found between the left amygdala and left dorsolateral prefrontal cortex. An increased right amygdala functional connectivity with right posterior and anterior lobes of the cerebellum, insula, superior temporal gyrus, putamen, and right amygdala were found in our study. Negative correlations between GAD scores and functional connectivity of the right amygdala with the cerebellum were also observed in the GAD adolescents. Conclusions: Adolescents with GAD have abnormalities in brain regions associated with the emotional processing pathways.

引用

页码：459 / 467

页数：9

共 48 条

[11]

Chao Gan Y, 2001, FRONT SYST NEUROSCI, V4, P1

[12] Child anxiety in primary care: Prevalent but untreated [J].