Medical applications of ternary nanocomposites based on hydroxyapatite/ytterbium oxide/graphene oxide: potential bone tissue engineering and antibacterial properties

被引：13

作者：

Albalwi, Hanan A. ^{[1
]}

El-Naggar, Mehrez E. ^{[2
]}

Abou Taleb, Manal ^{[1
,3
]}

Kalam, Abul ^{[4
,5
]}

Alghamdi, Noweir Ahmad ^{[6
]}

Mostafa, Mervat S. ^{[7
]}

Salem, Salem ^{[8
]}

Afifi, M. ^{[9
]}

机构：

[1] Prince Sattam Bin Abdulaziz Univ, Coll Sci & Humanities, Dept Chem, Al Kharj 11942, Saudi Arabia

[2] Natl Res Ctr, Inst Text Res & Technol, Cairo 16221, Egypt

[3] Egyptian Atom Energy Author, Natl Ctr Radiat Res & Technol NCRRT, Dept Polymer Chem, POB 7551, Cairo 11762, Egypt

[4] King Khalid Univ, Res Ctr Adv Mat Sci RCAMS, POB 9004, Abha 61413, Saudi Arabia

[5] King Khalid Univ, Coll Sci, Dept Chem, POB 9004, Abha 61413, Saudi Arabia

[6] Albaha Univ, Fac Sci, Dept Phys, Alaqiq 65779, Saudi Arabia

[7] Minist Mil Prod, Sci & Technol Ctr Excellence STCE, Cairo, Egypt

[8] Mil Med Acad, Dept Biochem & Clin Biochem, Cairo, Egypt

[9] Cairo Univ, Fac Nanotechnol Postgrad Studies, El Sheikh Zayed 12588, Egypt

来源：

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | 2022年 / 18卷

关键词：

Hydroxyapatite; Yb2O3; Graphene oxide; Cell viability; Tissue engineering; MECHANICAL-PROPERTIES; DOPED HYDROXYAPATITE; SURFACE MODIFICATION; GRAPHENE; NANOPARTICLES; TITANIUM; OSTEOGENESIS; FABRICATION; IMPROVEMENT; DEPOSITION;

D O I：

10.1016/j.jmrt.2022.04.106

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The spreading of diseases that cause major bone defects urges the need for fabricating bone substitutes. Hydroxyapatite (HAP)/ytterbium oxide (Yb2O3)/graphene oxide (GO) nanocomposite is fabricated and studied for its bioactivity, biocompatibility, microhardness, and antimicrobial activity to be used as bone replacement biomaterial. Moreover, the SEM micrographs revealed the improvement in scaffold porosity and biocompatibility, showing a particle size range from 0.1 to 1.5 mm. HAP/Yb2O3/GO shows enhanced roughness parameters in which the roughness average value reached 40.5 nm. Furthermore, the improved osteoblast cells attachment and proliferation obtained by HAP/Yb2O3/GO nanocomposite is confirmed via cell viability test the high value of 97.7 +/- 2.1%. HAP/Yb2O3/GO shows antibacterial properties against Escherichia coli and Staphylococcus aureus that evidenced with inhibition zone 12.5 +/- 1 mm and 11.8 +/- 1.1 mm, respectively. Besides, HAP/Yb2O3/GO showed the highest microhardness values of 3.4 +/- 0.2 GPa. (C) 2022 Published by Elsevier B.V.

引用

页码：4834 / 4845

页数：12

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