D2 receptor occupancy under recommended and high doses of olanzapine:: an iodine-123-iodobenzamide SPECT study

被引:30
作者
Meisenzahl, EM
Dresel, S
Frodl, T
Schmitt, GJE
Preuss, UW
Rossmüller, B
Tatsch, K
Mager, T
Hahn, K
Möller, HJ
机构
[1] Univ Munich, Dept Psychiat, D-80336 Munich, Germany
[2] Univ Munich, Dept Nucl Med, D-80336 Munich, Germany
关键词
atypical neuroleptics; dopamine D-2 receptor; I-123] IBZM; olanzapine; SPECT;
D O I
10.1177/026988110001400405
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of this study was to compare the degree of striatal dopamine D-2 receptor availability in patients treated with recommended (5-20 mg, mean dose 11.9 +/- 6.3 mg daily) and higher doses (25-40 mg, mean 32.1 +/- 5.6 mg daily) of the novel antipsychotic drug olanzapine by means of [I-123] IBZM Single photon emission computed tomography (SPECT). The results were compared to those of a group of 10 untreated, healthy, age- and sex-matched controls. The degree of dopamine D-2 receptor occupancy in the patient group was correlated with the presence of extrapyramidal symptoms (EPS). A total of 20 patients who met the DSM III R criteria for schizophrenia or schizoaffective disorder received a clinically effective antipsychotic monotherapy with olanzapine. The mean daily dose of olanzapine ranged from 0.05-0.6 mg/kg body weight. The dopamine Da receptor binding was reduced in all patients treated with olanzapine. Specific IBZM binding expressed as the [STR-BKG]/BKG ratio ranged from 0.13-0.61 (healthy controls 0.95). The D-2 receptor availability revealed an exponential dose-response relationship (r = - 0.85, p < 0.001). The frequency of EPS induced by olanzapine was considerably lower. Only one patient, treated with 40 mg olanzapine, suffered from severe EPS symptoms and had to be given biperiden. There were no significant differences in the presence of EPS symptoms between patients with recommended doses and those with higher doses of olanzapine.
引用
收藏
页码:364 / 370
页数:7
相关论文
共 42 条
[21]   D2 receptor occupancy of olanzapine pamoate depot using positron emission tomography:: An open-label study in patients with schizophrenia [J].
Mamo, David ;
Kapur, Shitij ;
Keshavan, Matcheri ;
Laruelle, Marc ;
Taylor, Cindy C. ;
Kothare, Prajakti A. ;
Barsoum, Penny ;
McDonnell, David .
NEUROPSYCHOPHARMACOLOGY, 2008, 33 (02) :298-304
[22]   D2 Receptor Occupancy of Olanzapine Pamoate Depot Using Positron Emission Tomography: An Open-label Study in Patients with Schizophrenia [J].
David Mamo ;
Shitij Kapur ;
Matcheri Keshavan ;
Marc Laruelle ;
Cindy C Taylor ;
Prajakti A Kothare ;
Penny Barsoum ;
David McDonnell .
Neuropsychopharmacology, 2008, 33 :298-304
[23]   Double-blind olanzapine vs. haloperidol D2 dopamine receptor blockade in schizophrenic patients:: a baseline-endpoint [123I]IBZM SPECT study [J].
Bernardo, M ;
Parellada, E ;
Lomeña, F ;
Catafau, AM ;
Font, M ;
Gómez, JC ;
López-Carrero, C ;
Gutiérrez, F ;
Pavía, J ;
Salamero, M .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2001, 107 (02) :87-97
[24]   Treatment response to olanzapine and haloperidol and its association with dopamine D2 receptor occupancy in first-episode psychosis [J].
Zipursky, RB ;
Christensen, BK ;
Daskalakis, Z ;
Epstein, I ;
Roy, P ;
Furimsky, I ;
Sanger, T ;
Kapur, S .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2005, 50 (08) :462-469
[25]   Striatal D2 receptor binding in 22q11 deletion syndrome: an [123I]IBZM SPECT study [J].
Boot, E. ;
Booij, J. ;
Zinkstok, J. R. ;
de Haan, L. ;
Linszen, D. H. ;
Baas, F. ;
Van Amelsvoort, T. A. .
JOURNAL OF PSYCHOPHARMACOLOGY, 2010, 24 (10) :1525-1531
[26]   In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol [J].
J. Tauscher ;
B. Küfferle ;
S. Asenbaum ;
P. Fischer ;
L. Pezawas ;
C. Barnas ;
S. Tauscher-Wisniewski ;
T. Brücke ;
S. Kasper .
Psychopharmacology, 1999, 141 :175-181
[27]   Exploration of Optimal Dosing Regimens of Haloperidol, a D2 Antagonist, via Modeling and Simulation Analysis in a D2 Receptor Occupancy Study [J].
Lim, Hyeong-Seok ;
Kim, Su Jin ;
Noh, Yook-Hwan ;
Lee, Byung Chul ;
Jin, Seok-Joon ;
Park, Hyun Soo ;
Kim, Soohyeon ;
Jang, In-Jin ;
Kim, Sang Eun .
PHARMACEUTICAL RESEARCH, 2013, 30 (03) :683-693
[28]   A single-scan protocol for absolute D2/3 receptor quantification with [123I]IBZM SPECT [J].
Tsartsalis, Stergios ;
Toumier, Benjamin B. ;
Aoun, Karl ;
Habiby, Selim ;
Pandolfo, Diego ;
Dimiziani, Andrea ;
Ginovart, Nathalie ;
Millet, Philippe .
NEUROIMAGE, 2017, 147 :461-472
[29]   Dopamine D-2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine - A I-123 IBZM single photon emission tomography (SPET) study [J].
Pilowsky, LS ;
Busatto, GF ;
Taylor, M ;
Costa, DC ;
Sharma, T ;
Sigmundsson, T ;
Ell, PJ ;
Nohria, V ;
Kerwin, RW .
PSYCHOPHARMACOLOGY, 1996, 124 (1-2) :148-153
[30]   A PET study of 5-HT2 and D-2 dopamine receptor occupancy induced by olanzapine in healthy subjects [J].
Nyberg, S ;
Farde, L ;
Halldin, C .
NEUROPSYCHOPHARMACOLOGY, 1997, 16 (01) :1-7