Perioperative change in neutrophil count predicts worse survival in esophageal squamous cell carcinoma

被引：4

作者：

Song, Qian ^{[1
,2
]}

Wu, Junzhou ^{[2
,3
]}

Wang, Sheng ^{[1
,2
]}

Xu, Songxiao ^{[1
,2
]}

机构：

[1] Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Clin Lab, Hangzhou 310022, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China

[3] Univ Chinese Acad Sci, Canc Hosp, Canc Res Inst, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

来源：

FUTURE ONCOLOGY | 2021年 / 17卷 / 34期

基金：

中国国家自然科学基金;

关键词：

esophageal squamous cell carcinoma; neutrophil; perioperative change; prognosis; survival; CIRCULATING TUMOR-CELLS; PROGNOSTIC-FACTOR; LYMPHOCYTE RATIO; T-CELLS; PROMOTE; CANCER; MICROENVIRONMENT; METASTASIS; EXPRESSION; RISK;

D O I：

10.2217/fon-2021-0371

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims: This study aimed to investigate the relationship between perioperative change in neutrophil count and survival of patients with esophageal squamous cell carcinoma. Method: Neutrophil change (Nc) (where Nc = post-surgery neutrophil count - pre-surgery neutrophil count) was counted according to data within 1 week before surgery and 2 weeks after surgery. Patients were divided into two groups, Nc >= 2.60 and Nc <2.60, according to the median of Nc. Results: Multivariate analysis revealed that Nc >= 2.60 was an independent prognostic marker for overall survival. Subgroup analysis suggested that the overall survival of male patients, patients aged <= 60 years, patients without vessel invasion and patients without nerve infiltration was dramatically worse for those with Nc Conclusion: Perioperative change in neutrophil count predicts worse survival in esophageal squamous cell carcinoma after surgery.

引用

页码：4721 / 4731

页数：11

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