High-frequency oscillations and focal seizures in epileptic rodents

被引:24
作者
Levesque, Maxime [1 ]
Avoli, Massimo [1 ,2 ,3 ,4 ]
机构
[1] Montreal Neurol Inst, 3801 Univ St,Room 795, Montreal, PQ H3A 2B4, Canada
[2] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
[3] McGill Univ, Dept Physiol, Montreal, PQ H3A 2B4, Canada
[4] Sapienza Univ Rome, Fac Med & Odontoiatria, Dept Expt Med, I-00185 Rome, Italy
基金
加拿大健康研究院;
关键词
High-frequency oscillations; Ripples; Fast ripples; Low-voltage fast onset seizures; Hypersynchronous-onset seizures; Animal models; TEMPORAL-LOBE EPILEPSY; SHARP-WAVE-RIPPLE; HIPPOCAMPAL NETWORK OSCILLATIONS; SPONTANEOUS RECURRENT SEIZURES; ENTORHINAL CORTEX; PILOCARPINE MODEL; ANTIEPILEPTIC DRUGS; INTERICTAL SPIKING; ICTAL ONSET; MOUSE MODEL;
D O I
10.1016/j.nbd.2018.12.016
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
High-pass filtering (> 80 Hz) of EEG signals has enabled neuroscientists to analyze high-frequency oscillations (HFOs; i.e., ripples: 80-200 Hz and fast ripples: 250-500 Hz) in epileptic patients presenting with focal seizures and in animal models mimicking this condition. Evidence obtained from these studies indicate that HFOs mirror pathological network activity that may initiate and sustain ictogenesis and epileptogenesis. HFOs are observed in temporal lobe regions of epileptic animals during interictal periods but they also occur before seizure onset and during the ictal period, suggesting that they can pinpoint to the mechanisms of seizure generation. Accordingly, ripples and fast ripples predominate during two specific seizure onset patterns termed low-voltage fast and hypersynchronous, respectively. In this review we will: (i) summarize these experimental studies; (ii) consider the evolution of HFOs over time during epileptogenesis; (iii) address data obtained with optogenetic stimulating procedures both in vitro and in vivo, and (iv) take into account the impact of anti-epileptic drugs on HFOs. We expect these findings to contribute to understanding the neuronal mechanisms leading to ictogenesis and epileptogenesis thus leading to the development of mechanistically targeted anti-epileptic strategies.
引用
收藏
页码:396 / 407
页数:12
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