Urinary mycoestrogens, body size and breast development in New Jersey girls

被引:78
作者
Bandera, Elisa V. [1 ,2 ]
Chandran, Urmila [1 ,2 ]
Buckley, Brian [3 ]
Lin, Yong [1 ,2 ]
Isukapalli, Sastry [3 ]
Marshall, Ian [4 ]
King, Melony [2 ]
Zarbl, Helmut [1 ,3 ]
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08901 USA
[2] Univ Med & Dent New Jersey, Sch Publ Hlth, Piscataway, NJ 08854 USA
[3] EOHSI, Piscataway, NJ 08854 USA
[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat Endocrinol, New Brunswick, NJ 08903 USA
关键词
Mycoestrogens; Zearalenone; Zeranol; Thelarche; Height; Weight; PRECOCIOUS SEXUAL DEVELOPMENT; MYCOTOXIN ZEARALENONE; EARLY-LIFE; PUBERTY; EXPOSURE; ESTROGEN; GROWTH; CONTAMINATION; METABOLITES; CHEMICALS;
D O I
10.1016/j.scitotenv.2011.09.029
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Despite extensive research and interest in endocrine disruptors, there are essentially no epidemiologic studies of estrogenic mycotoxins, such as zeranol and zearalenone (ZEA). ZEA mycoestrogens are present in grains and other plant foods through fungal contamination, and in animal products (e.g., meat, eggs, dairy products) through deliberate introduction of zeranol into livestock to enhance meat production, or by indirect contamination of animals through consumption of contaminated feedstuff. Zeranol is banned for use in animal husbandry in the European Union and other countries, but is still widely used in the US. Surprisingly, little is known about the health effects of these mycoestrogens, including their impact on puberty in girls, a period highly sensitive to estrogenic stimulation. Objectives and methods: We conducted a cross-sectional analysis among 163 girls, aged 9 and 10 years, participating in the Jersey Girl Study to measure urinary mycoestrogens and their possible relationship to body size and development. Results: We found that mycoestrogens were detectable in urine in 78.5% of the girls, and that urinary levels were predominantly associated with beef and popcorn intake. Furthermore, girls with detectable urinary ZEA mycoestrogen levels tended to be shorter and less likely to have reached the onset of breast development. Conclusions: Our findings suggest that ZEA mycoestrogens may exert anti-estrogenic effects similar to those reported for isoflavones. To our knowledge, this was the first evaluation of urinary mycoestrogens and their potential health effects in healthy girls. However, our findings need replication in larger studies with more heterogeneous populations, using a longitudinal approach. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:5221 / 5227
页数:7
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