Monkeypox in Germany

被引:27
作者
Hoffmann, Christian [1 ,2 ]
Jessen, Heiko [3 ]
Jessen, Arne [3 ]
Boesecke, Christoph [4 ]
Teichmann, Jorn [3 ]
Wyen, Christoph [5 ,6 ]
Noe, Sebastian [7 ]
Kreckel, Peter [8 ]
Koeppe, Siegfried [8 ]
Krauss, Anja-Sophie [9 ]
Schuler, Christoph [10 ]
Bickel, Markus [11 ]
Lenz, Johannes [10 ]
Scholten, Stefan [12 ]
Klausen, Gerd [13 ]
Lindhof, Harm-Henning [14 ]
Jensen, Bjorn [15 ]
Glaunsinger, Tobias [16 ]
Pauli, Ramona [17 ]
Haerter, Georg [18 ]
Radke, Billy [19 ]
Unger, Stefan [20 ]
Marquardt, Simone [21 ]
Masuhr, Anja [22 ]
Esser, Stefan [23 ]
Flettner, Tim Oliver [24 ]
Schaefer, Guido [1 ]
Schneider, Jochen [25 ]
Spinner, Christoph D. [25 ]
机构
[1] Infect Dis Med Ctr Hamburg, Hamburg, Germany
[2] Univ Hosp Schleswig Holstein, Campus Kiel:, Kiel, Germany
[3] Practice Jessen2 Colleagues, Berlin, Germany
[4] Bonn Univ Hosp, Dept Med 1, Venusberg Campus 1, D-53127 Bonn, Germany
[5] Ebertplatz, Practice, Cologne, Germany
[6] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany
[7] Goetheplatz, Med Care Ctr Munich, Munich, Germany
[8] Grp Practice Internal Med M 50De, Berlin, Germany
[9] Doctors Forum Infect Dis, Seestr, Berlin, Germany
[10] Turmstrasse Practice, Berlin, Germany
[11] Infect Dis Ctr, Frankfurt, Germany
[12] Dr Scholten Schneeweiss Partnership, Cologne, Germany
[13] Oranienburg Gate, Subspecialized Practice Infect Dis, Berlin, Germany
[14] Univ Hosp Dusseldorf, Dept Dermatol, Dusseldorf, Germany
[15] Univ Hosp Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, Dusseldorf, Germany
[16] Prenzlauer Berg Practice, Berlin, Germany
[17] Isartor, Med Care Ctr, Munich, Germany
[18] Medicover Ulm, Med Care Ctr, Ulm, Germany
[19] Checkpoint Berlin, Berlin, Germany
[20] Asklepios Hosp St Georg, Inst Interdisciplinary Med Ifi, Med Care Ctr Ifi Inst, Block L, Hamburg, Germany
[21] Frietsch Roll Marquardt Grp Practice, Stuttgart, Germany
[22] Auguste Victoria Clin, Berlin, Germany
[23] Univ Hosp Essen, Clin & Outpatient Clin Dermatol Venerol & Allergo, HPSTD Outpatient Dept, Essen, Germany
[24] Pempelfort Family Practice, Dusseldorf, Germany
[25] Tech Univ Munich, Rechts Isar Univ Hosp, Clin & Outpatient Dept Internal Med 2, Munich, Germany
来源
DEUTSCHES ARZTEBLATT INTERNATIONAL | 2022年 / 119卷 / 33-34期
关键词
D O I
10.3238/arztebl.m2022.0287
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Many cases of monkeypox have been reported across Europe from early May 2022 onward. Initial publications suggest that nearly all of the affected persons to date have been men who have sex with men (MSM). Methods: To characterize the German cases, an anonymous questionnaire was sent via the mailing lists of the German AIDS Society (Deutsche AIDS-Gesellschaft, DAIG) and the German Association of Outpatient Physicians for Infectious Diseases and HIV Medicine (Deutsche Arbeitsgemeinschaft ambulant tatiger Arztinnen und Arzte fur Infektionskrankheiten und HIV-Medizin e.V., DAGNAE). Results: 301 PCR-verified cases had been registered as of 23 June 2022. All of the affected persons were MSM, including 141 (46.7%) with HIV infection and 135 (44.7%) with pre-exposure prophylaxis (PrEP). The great majority of skin lesions were in the anal and genital areas. The most common general symptoms were fever, headache, limb pain, and, often, painfully swollen lymph nodes. Most infections to date have taken a relatively mild course: 5.0% of the patients were hospitalized, and none died. A high frequency of sexually transmitted infections (STI) was noted: only 41.0% of the patients had not been given a diagnosis of an STI in the six months before their monkeypox infection. Conclusion: Monkeypox seems to be establishing itself as a new type of STI among MSM. In view of the rising case numbers, there is a need for a rapid information and vaccination campaign in the population at risk. Heightened alertness among physicians is needed as well.
引用
收藏
页码:551 / 557
页数:7
相关论文
共 25 条
[1]  
Adler H, 2022, Lancet Infect Dis, V22, P1473
[2]   Virulence differences between monkeypox virus isolates from West Africa and the Congo basin [J].
Chen, NH ;
Li, GY ;
Liszewski, MK ;
Atkinson, JP ;
Jahrling, PB ;
Feng, ZH ;
Schriewer, J ;
Buck, C ;
Wang, CL ;
Lefkowitz, EJ ;
Esposito, JJ ;
Harms, T ;
Damon, IK ;
Roper, RL ;
Upton, C ;
Buller, RML .
VIROLOGY, 2005, 340 (01) :46-63
[3]   Smallpox vaccine does not protect Macaques with AIDS from a lethal Monkeypox virus challenge [J].
Edghill-Smith, Y ;
Bray, M ;
Whitehouse, CA ;
Miller, D ;
Mucker, E ;
Manischewitz, J ;
King, LR ;
Robert-Guroff, M ;
Hryniewicz, A ;
Venzon, D ;
Meseda, C ;
Weir, J ;
Nalca, A ;
Livingston, V ;
Wells, J ;
Lewis, MG ;
Huggins, J ;
Zwiers, SH ;
Golding, H ;
Franchini, G .
JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (03) :372-381
[4]   THE TRANSMISSION POTENTIAL OF MONKEYPOX VIRUS IN HUMAN-POPULATIONS [J].
FINE, PEM ;
JEZEK, Z ;
GRAB, B ;
DIXON, H .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1988, 17 (03) :643-650
[5]   Evaluation of human-to-human transmission of monkeypox from infected patients to health care workers [J].
Fleischauer, AT ;
Kile, JC ;
Davidson, M ;
Fischer, M ;
Karem, KL ;
Teclaw, R ;
Messersmith, H ;
Pontones, P ;
Beard, BA ;
Braden, ZH ;
Cono, J ;
Sejvar, JJ ;
Khan, AS ;
Damon, I ;
Kuehnert, MJ .
CLINICAL INFECTIOUS DISEASES, 2005, 40 (05) :689-694
[6]   Multiple lineages of monkeypox virus detected in the United States, 2021-2022 [J].
Gigante, Crystal M. ;
Korber, Bette ;
Seabolt, Matthew H. ;
Wilkins, Kimberly ;
Davidson, Whitni ;
Rao, Agam K. ;
Zhao, Hui ;
Smith, Todd G. ;
Hughes, Christine M. ;
Minhaj, Faisal ;
Waltenburg, Michelle A. ;
Theiler, James ;
Smole, Sandra ;
Gallagher, Glen R. ;
Blythe, David ;
Myers, Robert ;
Schulte, Joann ;
Stringer, Joey ;
Lee, Philip ;
Mendoza, Rafael M. ;
Griffin-Thomas, Latoya A. ;
Crain, Jenny ;
Murray, Jade ;
Atkinson, Annette ;
Gonzalez, Anthony H. ;
Nash, June ;
Batra, Dhwani ;
Damon, Inger ;
McQuiston, Jennifer ;
Hutson, Christina L. ;
McCollum, Andrea M. ;
Li, Yu .
SCIENCE, 2022, 378 (6619) :560-564
[7]   Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections [J].
Gilchuk, Iuliia ;
Gilchuk, Pavlo ;
Sapparapu, Gopal ;
Lampley, Rebecca ;
Singh, Vidisha ;
Kose, Nurgun ;
Blum, David L. ;
Hughes, Laura J. ;
Satheshkumar, Panayampalli S. ;
Townsend, Michael B. ;
Kondas, Ashley V. ;
Reed, Zachary ;
Weiner, Zachary ;
Olson, Victoria A. ;
Hammarlund, Erika ;
Raue, Hans-Peter ;
Slifka, Mark K. ;
Slaughter, James C. ;
Graham, Barney S. ;
Edwards, Kathryn M. ;
Eisenberg, Roselyn J. ;
Cohen, Gary H. ;
Joyce, Sebastian ;
Crowe, James E., Jr. .
CELL, 2016, 167 (03) :684-+
[8]  
Giorgi FM, 2022, BIORXIV
[9]   Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox [J].
Hammarlund, E ;
Lewis, MW ;
Carter, SV ;
Amanna, I ;
Hansen, SG ;
Strelow, LI ;
Wong, SW ;
Yoshihara, P ;
Hanifin, JM ;
Slifka, MK .
NATURE MEDICINE, 2005, 11 (09) :1005-1011
[10]   Clinical characteristics of human monkeypox, and risk factors for severe disease [J].
Huhn, GD ;
Bauer, AM ;
Yorita, K ;
Graham, MB ;
Sejvar, J ;
Likos, A ;
Damon, IK ;
Reynolds, MG ;
Kuehnert, MJ .
CLINICAL INFECTIOUS DISEASES, 2005, 41 (12) :1742-1751