Synthesis and enantioseparation characteristics of a novel mono-6-deoxy-(2,4-dihydroxybenzimide)-β-cyclodextrin as a chiral stationary phase in high-performance liquid chromatography

被引：17

作者：

Li, Xia ^{[1
]}

Zhou, Zhiming ^{[1
,2
]}

Dai, Li ^{[1
]}

Zhou, Wenhong ^{[1
]}

Wang, Jinliang ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Chem Engn & Environm, R&D Ctr Pharmaceut, Beijing 100081, Peoples R China

[2] Beijing Inst Technol, State Key Lab Explos Sci & Technol, Beijing 100081, Peoples R China

来源：

TALANTA | 2011年 / 86卷

基金：

中国国家自然科学基金;

关键词：

Cyclodextrin derivative; Stationary phase; Chiral compounds; High-performance liquid chromatography; Enantioseparation; ENANTIOMERIC SEPARATION; CYCLODEXTRIN DERIVATIVES; BONDED SILICA; RECOGNITION;

D O I：

10.1016/j.talanta.2011.09.006

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel chiral selector mono-6-deoxy-(2,4-dihydroxybenzimide)-beta-CD (MDHB-beta-CD) in which the derivatized group and the cavity of CD is linked by CH(2)-N=C group, was successfully prepared, and the structural characteristics were determined by Fr-IR, (1)H and (13)C NMR, MALDITOF-MS and element analysis. The corresponding stationary phase (CSP) was used in HPLC and the enantioseparation performance was investigated using chiral 1-phenyl-2-nitroethanol derivatives as test samples in the reverse-phase mode composed of methanol/water and acetonitrile/TEAA. Better separation abilities and excellent enantioselectivities (alpha > 1.26, R(S) > 1.73) were obtained on MDHB-beta-CD CSP for these chiral compounds in the methanol/water mobile phase. (C) 2011 Elsevier By. All rights reserved.

引用

页码：452 / 456

页数：5

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