The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer

被引:53
作者
Chen, Xue [1 ,2 ,3 ,4 ]
Bode, Ann M. [5 ]
Dong, Zigang [5 ]
Cao, Ya [1 ,2 ,3 ,4 ]
机构
[1] Cent S Univ, Mol Imaging Res Ctr, Xiangya Hosp, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China
[2] Cent S Univ, Canc Res Inst, Changsha, Hunan, Peoples R China
[3] Cent S Univ, Key Lab, Chinese Minist Educ, Changsha, Hunan, Peoples R China
[4] Cent S Univ, State Key Lab Carcinogenesis, Chinese Minist Publ Hlth, Changsha, Hunan, Peoples R China
[5] Univ Minnesota, Hormel Inst, 801 16th Ave NE, Austin, MN 55912 USA
基金
国家高技术研究发展计划(863计划);
关键词
metastasis; carcinogenesis virus; signaling pathway; cancer progression; EPSTEIN-BARR-VIRUS; HEPATITIS-B-VIRUS; CIRCULATING TUMOR-CELLS; E-CADHERIN EXPRESSION; PHASE-I TRIAL; NASOPHARYNGEAL CARCINOMA; TGF-BETA; HEPATOCELLULAR-CARCINOMA; DNA METHYLATION; X-PROTEIN;
D O I
10.1096/fj.201600388R
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The epithelial-mesenchymal transition (EMT), defined as transdifferentiation of epithelial cells into mesenchymal cells, is critical for embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. Recently, the role of EMT in carcinogenesis has attracted much attention. Oncoviruses, including human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and hepatitis B and C viruses (HBVs, HCVs), are known to be involved in the etiology of cancer and have been found to play important roles in cancer metastasis, especially in the EMT process. The HPV encoded oncoproteins E6 and E7 (E6/E7), EBV latent membrane protein-1 and -2A, EBV nuclear antigen, HBV-encoded X antigen, and nonstructural HCV protein 5A are all involved in the regulation of EMT. This review primarily focuses on the role of oncoviruses and their encoded proteins or signaling pathways in the EMT process. Understanding their roles will help us in the development of effective strategies for prevention and treatment of virus-related cancers.Chen, X., Bode, A. M., Dong, Z., Cao, Y. The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer.
引用
收藏
页码:3001 / 3010
页数:10
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