Decreased Expression of Lysosomal Alpha-Galactosiase A Gene in Sporadic Parkinson's Disease

被引：11

作者：

Wu, Guanghua ^{[1
,2
]}

Huang, Jian ^{[1
]}

Feng, Xungang ^{[3
]}

Zhang, Aimei ^{[3
]}

Li, Jifeng ^{[3
]}

Pang, Shuchao ^{[1
]}

Gu, Kejin ^{[3
]}

Dong, Haixin ^{[4
]}

Zhang, Junping ^{[1
]}

Gao, Huijie ^{[5
]}

Yan, Bo ^{[1
]}

机构：

[1] Affiliated Hosp, Jining Med Coll, Shandong Prov Key Lab Cardiac Dis Diag & Treatmen, Jining 272029, Shandong, Peoples R China

[2] Affiliated Hosp, Jining Med Coll, Div Cardiac Surg, Jining 272029, Shandong, Peoples R China

[3] Affiliated Hosp, Jining Med Coll, Div Neurol, Jining 272029, Shandong, Peoples R China

[4] Affiliated Hosp, Jining Med Coll, Div Expt Med, Jining 272029, Shandong, Peoples R China

[5] Jining Med Coll, Dept Immunol, Jining 272067, Shandong, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2011年 / 36卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; Lysosome; Alpha-galactosidase A; Gene expression; Leukocytes; AUTOPHAGY; SYNUCLEIN; STORAGE; ACCUMULATION; DEGRADATION; DYSFUNCTION; NEURODEGENERATION; PATHOGENESIS; DISORDERS; MUTATIONS;

D O I：

10.1007/s11064-011-0516-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's disease (PD) is a progressive neurodegenerative disease. To date, the causal genes and variants associated with sporadic PD are largely unknown. Accumulating evidence demonstrates that autophagy delivers alpha-syncuclein proteins to lysosome for degradation and dysfunctional autophagy is involved in the PD pathogenesis. We have previously screened a group of lysosomal hydrolases and found that alpha-galactosidase A (GLA) activity is significantly decreased in the peripheral leukocytes of sporadic PD patients. In this study, GLA transcript and protein levels were semi-quantitatively examined. The GLA transcript (P = 0.020) and protein (P = 0.027) levels in the peripheral leukocytes of sporadic PD patients were significantly decreased, compared to age- and sex-matched healthy controls. Furthermore, decreased GLA gene expression levels were strongly associated with sporadic PD (OR 3.33, 95%CI 1.17-9.52, P = 0.024). Therefore, our data suggest that insufficient GLA activity may contribute to the pathogenesis of sporadic PD. The underlying molecular mechanisms remain to be determined.

引用

页码：1939 / 1944

页数：6

共 48 条

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