Isolation and purification of glycyrrhizic acid with solvent extraction

被引：32
作者：
Niu, GG [1 ]
Xie, YC [1 ]
Lou, HF [1 ]
Liu, HZ [1 ]
机构：
[1] Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Lab Separat Sci & Engn, Beijing 100080, Peoples R China
来源：
SEPARATION AND PURIFICATION TECHNOLOGY | 2005年 / 44卷 / 03期
基金：
中国国家自然科学基金;
关键词：
liquorice; glycyrrhizic acid; solvent extraction; purification;
D O I：
10.1016/j.seppur.2004.05.011
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Solvent extraction of glycyrrhizic acid (GA) from liquorice leaching solution was studied with tributyl phosphate, trialkylphosphine oxide, n-hexanol and 2-ethyl-hexanol as extractants. The results showed that GA was easily extracted into the organic phase in molecular state by the formation of hydrogen bond. pH was the key factor influencing the selectivity during extraction and stripping. The extraction mechanism was studied with transmitting electron microscopy and analysis of solute distribution. It was deduced that glycyrrhizic acid was extracted into the organic solvent in the form of molecular aggregation rather than as single molecules. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：189 / 196
页数：8
相关论文
共 23 条
  • [1] MECHANISM OF ANTIINFLAMMATORY ACTION OF GLYCYRRHIZIN - EFFECT ON NEUTROPHIL FUNCTIONS INCLUDING REACTIVE OXYGEN SPECIES GENERATION
    AKAMATSU, H
    KOMURA, J
    ASADA, Y
    NIWA, Y
    [J]. PLANTA MEDICA, 1991, 57 (02) : 119 - 121
  • [2] Bi LiangWu, 1997, Chemistry and Industry of Forest Products, V17, P41
  • [3] FENG FS, 1997, NAT PROD RES DEV, V10, P60
  • [4] THE ANTI-INFLAMMATORY ACTIVITY OF GLYCYRRHETINIC ACID AND DERIVATIVES
    FINNEY, RSH
    SOMERS, GF
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1958, 10 (10) : 613 - 620
  • [5] Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: In vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice
    Fuhrman, B
    Buch, S
    Vaya, J
    Belinky, PA
    Coleman, R
    Hayek, T
    Aviram, M
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1997, 66 (02) : 267 - 275
  • [6] GUAN YX, 2001, P 3 CHIN KOR C SEP S, P575
  • [7] Hirayama C., 1983, ASIAN MED J, V26, P423, DOI DOI 10.1093/JNCI/53.5.1515
  • [8] HU XE, 1996, J TAINGHU U SCI TECH, V36, P13
  • [9] INHIBITORY EFFECT OF GLYCYRRHIZIN ON THE INVITRO INFECTIVITY AND CYTOPATHIC ACTIVITY OF THE HUMAN-IMMUNODEFICIENCY-VIRUS [HIV(HTLV-III/LAV)]
    ITO, M
    NAKASHIMA, H
    BABA, M
    PAUWELS, R
    DECLERCQ, E
    SHIGETA, S
    YAMAMOTO, N
    [J]. ANTIVIRAL RESEARCH, 1987, 7 (03) : 127 - 137
  • [10] Li Q. L., 1998, J INSTRUM ANAL, V17, P37
123