Optical phased array neural probes for beam-steering in brain tissue

被引：30
|
作者：
Sacher, Wesley D. [1 ,2 ,3 ]
Chen, Fu-Der [2 ,3 ]
Moradi-Chameh, Homeira [4 ]
Liu, Xinyu [1 ]
Almog, Ilan Felts [2 ]
Lordello, Thomas [2 ]
Chang, Michael [4 ]
Naderian, Azadeh [4 ]
Fowler, Trevor M. [1 ]
Segev, Eran [1 ]
Xue, Tianyuan [2 ]
Mahallati, Sara [4 ]
Valiante, Taufik A. [4 ,5 ,6 ]
Moreaux, Laurent C. [1 ]
Poon, Joyce K. S. [2 ,3 ]
Roukes, Michael L. [1 ]
机构：
[1] CALTECH, Div Phys Math & Astron, Pasadena, CA 91125 USA
[2] Univ Toronto, Dept Elect & Comp Engn, 10 Kings Coll Rd, Toronto, ON M5S 3G4, Canada
[3] Max Planck Inst Microstruct Phys, Weinberg 2, D-06120 Halle, Germany
[4] Univ Hlth Network, Krembil Res Inst, Div Clin & Computat Neurosci, Toronto, ON, Canada
[5] Univ Toronto, Toronto Western Hosp, Dept Surg, Div Neurosurg, Toronto, ON, Canada
[6] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada
来源：
OPTICS LETTERS | 2022年 / 47卷 / 05期
基金：
加拿大自然科学与工程研究理事会; 美国国家卫生研究院; 加拿大健康研究院;
关键词：
CIRCUIT ACTIVITY;
D O I：
10.1364/OL.441609
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering in vitro. Beam formation in brain tissue is simulated and characterized. The probes are used for optogenetic stimulation and calcium imaging. (C) 2022 Optical Society of America
引用
收藏
页码：1073 / 1076
页数：4
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