Optical phased array neural probes for beam-steering in brain tissue

被引：36

作者：

Sacher, Wesley D. ^{[1
,2
,3
]}

Chen, Fu-Der ^{[2
,3
]}

Moradi-Chameh, Homeira ^{[4
]}

Liu, Xinyu ^{[1
]}

Almog, Ilan Felts ^{[2
]}

Lordello, Thomas ^{[2
]}

Chang, Michael ^{[4
]}

Naderian, Azadeh ^{[4
]}

Fowler, Trevor M. ^{[1
]}

Segev, Eran ^{[1
]}

Xue, Tianyuan ^{[2
]}

Mahallati, Sara ^{[4
]}

Valiante, Taufik A. ^{[4
,5
,6
]}

Moreaux, Laurent C. ^{[1
]}

Poon, Joyce K. S. ^{[2
,3
]}

Roukes, Michael L. ^{[1
]}

机构：

[1] CALTECH, Div Phys Math & Astron, Pasadena, CA 91125 USA

[2] Univ Toronto, Dept Elect & Comp Engn, 10 Kings Coll Rd, Toronto, ON M5S 3G4, Canada

[3] Max Planck Inst Microstruct Phys, Weinberg 2, D-06120 Halle, Germany

[4] Univ Hlth Network, Krembil Res Inst, Div Clin & Computat Neurosci, Toronto, ON, Canada

[5] Univ Toronto, Toronto Western Hosp, Dept Surg, Div Neurosurg, Toronto, ON, Canada

[6] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada

来源：

OPTICS LETTERS | 2022年 / 47卷 / 05期

基金：

加拿大健康研究院; 美国国家卫生研究院; 加拿大自然科学与工程研究理事会;

关键词：

CIRCUIT ACTIVITY;

D O I：

10.1364/OL.441609

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering in vitro. Beam formation in brain tissue is simulated and characterized. The probes are used for optogenetic stimulation and calcium imaging. (C) 2022 Optical Society of America

引用

页码：1073 / 1076

页数：4

共 22 条

[1] Thy1-GCaMP6 Transgenic Mice for Neuronal Population In Vivo [J].

Dana, Hod ;

Chen, Tsai-Wen ;

Hu, Amy ;

Shields, Brenda C. ;

Guo, Caiying ;

Looger, Loren L. ;

Kim, Douglas S. ;

Svoboda, Karel .

PLOS ONE, 2014, 9 (09)

[2] Optogenetics: 10 years of microbial opsins in neuroscience [J].

Deisseroth, Karl .

NATURE NEUROSCIENCE, 2015, 18 (09) :1213-1225

[3] Silicon photonic integration in telecommunications [J].

Doerr, Christopher R. .

FRONTIERS IN PHYSICS, 2015, 3 (AUG)

[4] High-resolution aliasing-free optical beam steering [J].

Hutchison, David N. ;

Sun, Jie ;

Doylend, Jonathan K. ;

Kumar, Ranjeet ;

Heck, John ;

Kim, Woosung ;

Phare, Christopher T. ;

Feshali, Avi ;

Rong, Haisheng .

OPTICA, 2016, 3 (08) :887-890

[5] On-chip silicon optical phased array for two-dimensional beam steering [J].

Kwong, David ;

Hosseini, Amir ;

Covey, John ;

Zhang, Yang ;

Xu, Xiaochuan ;

Subbaraman, Harish ;

Chen, Ray T. .

OPTICS LETTERS, 2014, 39 (04) :941-944

[6] Proximal and distal modulation of neural activity by spatially confined optogenetic activation with an integrated high-density optoelectrode [J].

Libbrecht, Sarah ;

Hoffman, Luis ;

Welkenhuysen, Marleen ;

Van den Haute, Chris ;

Baekelandt, Veerle ;

Braeken, Dries ;

Haesler, Sebastian .

JOURNAL OF NEUROPHYSIOLOGY, 2018, 120 (01) :149-161

[7] Optical phased array beam steering in the mid-infrared on an InP-based platform [J].

Midkiff, Jason ;

Yoo, Kyoung Min ;

Shin, Jong-Dug ;

Dalir, Hamed ;

Teimourpour, Mohammad ;

Chen, Ray T. .

OPTICA, 2020, 7 (11) :1544-1547

[8] Reconfigurable nanophotonic silicon probes for sub-millisecond deep-brain optical stimulation [J].

Mohanty, Aseema ;

Li, Qian ;

Tadayon, Mohammad Amin ;

Roberts, Samantha P. ;

Bhatt, Gaurang R. ;

Shim, Euijae ;

Ji, Xingchen ;

Cardenas, Jaime ;

Miller, Steven A. ;

Kepecs, Adam ;

Lipson, Michal .

NATURE BIOMEDICAL ENGINEERING, 2020, 4 (02) :223-231

[9] Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity-at Depth and in Real Time [J].

Moreaux, Laurent C. ;

Yatsenko, Dimitri ;

Sacher, Wesley D. ;

Choi, Jaebin ;

Lee, Changhyuk ;

Kubat, Nicole J. ;

Cotton, R. James ;

Boyden, Edward S. ;

Lin, Michael Z. ;

Tian, Lin ;

Tolias, Andreas S. ;

Poon, Joyce K. S. ;

Shepard, Kenneth L. ;

Roukes, Michael L. .

NEURON, 2020, 108 (01) :66-92

[10] Simultaneous all-optical manipulation and recording of neural circuit activity with cellular resolution in vivo [J].

Packer, Adam M. ;

Russell, Lloyd E. ;

Dalgleish, Henry W. P. ;

Haeusser, Michael .

NATURE METHODS, 2015, 12 (02) :140-U86

← 1 2 3 →