The effect of density-dependent treatment and behavior change on the dynamics of HIV transmission

被引:35
作者
Hsieh, YH [1 ]
Sheu, SP [1 ]
机构
[1] Natl Chunghsing Univ, Dept Appl Math, Taichung 402, Taiwan
关键词
epidemiological models; HIV transmission; population with varying size; density-dependent treatment/behavior change; global analysis; existence and uniqueness of endemic steady state;
D O I
10.1007/s002850100087
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this work, we propose a model for heterosexual transmission of HIV/AIDS in a population of varying size with an intervention program in which treatment and/or behavior change of the infecteds occur as an increasing function of the density of the infected class in the population. This assumption has socio-economic implications which is important for public health considerations since density-dependent treatment/behavior change may be more cost-saving than a program where treatment/behavior change occurs linearly with respect to the number of infecteds. We will make use of the conservation law of total sexual contacts which enables us to reduce the two-sex model to a simpler one-sex formulation. Analytical results will be given. Unlike a similar model With linear treatment/behavior change in Hsieh (1996) where conditions were obtained for the eradication of disease, we will show that density-dependent treatment/behavior change cannot eradicate the disease if the disease is able to persist without any treatment/behavior change. This work demonstrates the need to further understand how treatment/behavior change occurs in a society with varying population.
引用
收藏
页码:69 / 80
页数:12
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