Steroid sulfatase inhibitors: A review covering the promising 2000-2010 decade

被引：61
作者：
Maltais, Rene
Poirier, Donald [1 ]
机构：
[1] CHUQ CHUL, Med Chem Lab, Res Ctr, Endocrinol & Genom Unit, Quebec City, PQ G1V 4G2, Canada
来源：
STEROIDS | 2011年 / 76卷 / 10-11期
基金：
加拿大健康研究院;
关键词：
Sulfatase; Enzyme; Inhibitor; Sulfamate; Hormone; VITRO BIOCHEMICAL EVALUATION; DEPENDENT BREAST-CANCER; AC RING MIMICS; ESTRONE-SULFATASE; IN-VITRO; AROMATASE INHIBITORS; POTENT INHIBITORS; DUAL AROMATASE; REVERSIBLE INHIBITORS; ENDOMETRIOTIC IMPLANTS;
D O I：
10.1016/j.steroids.2011.03.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The steroid sulfatase (STS) plays a major role in the regulation of steroid hormone concentrations in several human tissues and target organs and therefore, represents an interesting target to regulate estrogen and androgen levels implicated in different diseases. In this review article, the emphasis is put on STS inhibitors reported in the fruitful 2000-2010 decade, which consolidated the first ones that were previously developed (1990-1999). The inhibitors reviewed are divided into four categories according to the fact that they are sulfamoylatecl or not or that they have a steroid nucleus or not. Other topics such as function, localization, structure and mechanism as well as applications of STS inhibitors are also briefly discussed to complement the information on this crucial steroidogenic enzyme and its inhibitors. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：929 / 948
页数：20
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