The many faces of ghrelin:: new perspectives for nutrition research?

被引：37
作者：
Otto, B [1 ]
Spranger, J
Benoit, SC
Clegg, DJ
Tschöp, MH
机构：
[1] Univ Hosp Munich, Med Dept Innenstadt, Munich, Germany
[2] German Inst Human Nutr Potsdam Rehbrucke, Dept Clin Nutr, Potsdam, Germany
[3] German Inst Human Nutr Potsdam Rehbrucke, Dept Pharmacol, Potsdam, Germany
[4] Univ Hosp Berlin, Dept Endocrinol Diabetol & Nutr, Berlin, Germany
[5] Univ Cincinnati, Dept Psychiat, Cincinnati, OH USA
来源：
BRITISH JOURNAL OF NUTRITION | 2005年 / 93卷 / 06期
关键词：
ghrelin; diabetes; obesity; anorexia; energy balance;
D O I：
10.1079/BJN20051446
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The appetite-modulating peptide ghrelin is predominantly produced and secreted by the stomach and shows a strong growth hormone-releasing activity, which is mediated by the activation of the so-called growth hormone secretagogue type 1a receptor. Ghrelin is involved in the regulation of energy balance by increasing food intake and reducing fat utilization. Additionally, it stimulates lactotroph and corticotroph function, influences the pituitary gonadal axis, inhibits pro-inflammatory cytokine expression, controls gastric motility and acid secretion and influences pancreatic exocrine and endocrine function, as well as impacting on glucose metabolism. This review summarizes the known functions of ghrelin and its role in the regulation of the gut-brain axis.
引用
收藏
页码：765 / 771
页数：7
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