Association between serum uric acid and proteinuria in patients with type 2 diabetes and stages 1 and 2 chronic kidney disease

Background: - Interaction between serum uric acid level and diabetic nephropathy is a matter of debate. This study is designed to examine the association between serum uric acid (SUA) level and proteinuria in in type 2 diabetes patients with stages 1 and 2 chronic kidney disease (CKD). Material and methods: - For this cross-sectional study, type 2 diabetic patients aged >= 20 years were recruited from two clinics in Kermanshah city from February 2014 to February 2016. Demographic, anthropometric and metabolic data of participants were obtained. Male and female participants were analyzed separately by logistic regression. Results: - A total of 432 patients (63.7% women) with a mean +/- standard deviation (SD) age of 54.68 +/- 9.96 years were analyzed. Multivariate logistic regression model including age, diabetes duration, body mass index (BMI), estimated glomerular filtration rate (eGFR), fasting blood glucose (FBS), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and SUA showed that in male participants, SUA, FBS, DBP and eGFR significantly predicted proteinuria, while in female gender, SUA, HDL-C, DM duration and age were the independent correlates of proteinuria. Conclusions: - Serum uric acid significantly predicted proteinuria in both genders. Moreover, in women with type 2 diabetes and stages 1 and 2 CKD, while the association between eGFR and proteinuria was lost, serum uric acid level was independently correlated with the presence of proteinuria.