Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death

被引：2

作者：

Votkina, Darya E. ^{[1
]}

Plotnikov, Evgenii, V ^{[1
]}

Petunin, Pavel, V ^{[1
]}

Berdinskaya, Elizaveta S. ^{[1
]}

Tretyakova, Maria S. ^{[1
]}

Audran, Gerard ^{[2
]}

Marque, Sylvain R. A. ^{[2
]}

Postnikov, Pavel S. ^{[1
,3
]}

机构：

[1] Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk 634050, Russia

[2] Aix Marseille Univ, CNRS, ICR, Case 551, F-13397 Marseille 20, France

[3] Univ Chem & Technol, Dept Solid State Engn, Prague 16628, Czech Republic

来源：

MOLECULAR PHARMACEUTICS | 2022年 / 19卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

alkylated verdazyls; cancer cell death; photolysis; PHOTODYNAMIC THERAPY; ALKOXYAMINES;

D O I：

10.1021/acs.molpharmaceut.1c00780

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Two alkylated verdazyl radicals (AlkVZs) were investigated as active compounds for photoinitiated controlled MCF7 cell death. Observed results unambiguously showed that AlkVZ could be a potential structural moiety for the design of a novel family of photodynamic therapy agents. The main advantage of the proposed substances is an oxygen-independent generation of active radicals, which play a pivotal role in the treatment of oxygen-deficient tumors.

引用

页码：354 / 357

页数：4

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