The Correlation of Serum Osteoprotegerin with Non-Traditional Cardiovascular Risk Factors and Arterial Stiffness in Patients with Pre-Dialysis Chronic Kidney Disease: Results from the KNOW-CKD Study

被引：9

作者：

Chae, Seung Yun ^{[1
]}

Chung, WooKyung ^{[2
]}

Kim, Yeong Hoon ^{[3
]}

Oh, Yun Kyu ^{[4
]}

Lee, Joongyub ^{[5
]}

Choi, Kyu Hun ^{[6
]}

Ahn, Curie ^{[7
]}

Kim, Yong-Soo ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Internal Med, 222 Banpo Daero, Seoul 06591, South Korea

[2] Gachon Univ, Gil Med Ctr, Dept Internal Med, Incheon, South Korea

[3] Inje Univ, Dept Internal Med, Busan Paik Hosp, Busan, South Korea

[4] Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul, South Korea

[5] Inha Univ, Dept Prevent & Management, Sch Med, Incheon, South Korea

[6] Yonsei Univ, Coll Med, Inst Kidney Dis Res, Dept Internal Med, Seoul, South Korea

[7] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2018年 / 33卷 / 53期

关键词：

Serum Osteoprotegerin; Non-Traditional Cardiovascular Risk Factors; Brachial-Ankle Pulse Wave Velocity; Chronic Kidney Disease; KAPPA-B LIGAND; VASCULAR CALCIFICATION; PLASMA OSTEOPROTEGERIN; GENERAL-POPULATION; RECEPTOR ACTIVATOR; METABOLIC SYNDROME; ALL-CAUSE; MORTALITY; ASSOCIATION; LEVEL;

D O I：

10.3346/jkms.2018.33.e322

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD. Methods: We cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea. Results: Along with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total CO2 content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model. Conclusion: Non-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD.

引用

页数：14

共 40 条

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