The Combined Regulation of Long Non-coding RNA and RNA-Binding Proteins in Atherosclerosis

被引：13

作者：

Ding, Yuanyuan ^{[1
]}

Yin, Ruihua ^{[1
]}

Zhang, Shuai ^{[1
]}

Xiao, Qi ^{[1
]}

Zhao, Hongqin ^{[1
]}

Pan, Xudong ^{[1
]}

Zhu, Xiaoyan ^{[2
]}

机构：

[1] Qingdao Univ, Dept Neurol, Affiliated Hosp, Qingdao, Peoples R China

[2] Qingdao Univ, Dept Crit Care Med, Affiliated Hosp, Qingdao, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; RNA-binding protein; atherosclerosis; endothelial cells; macrophages; smooth muscle cells; SMOOTH-MUSCLE-CELL; SIGNAL-TRANSDUCTION PATHWAY; VASCULAR ENDOTHELIAL-CELLS; CORONARY-ARTERY-DISEASE; PROMOTES PROLIFERATION; CHOLESTEROL EFFLUX; MACROPHAGE ACTIVATION; INFLAMMATORY RESPONSE; DOWN-REGULATION; UP-REGULATION;

D O I：

10.3389/fcvm.2021.731958

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a complex disease closely related to the function of endothelial cells (ECs), monocytes/macrophages, and vascular smooth muscle cells (VSMCs). Despite a good understanding of the pathogenesis of atherosclerosis, the underlying molecular mechanisms are still only poorly understood. Therefore, atherosclerosis continues to be an important clinical issue worthy of further research. Recent evidence has shown that long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) can serve as important regulators of cellular function in atherosclerosis. Besides, several studies have shown that lncRNAs are partly dependent on the specific interaction with RBPs to exert their function. This review summarizes the important contributions of lncRNAs and RBPs in atherosclerosis and provides novel and comprehensible interaction models of lncRNAs and RBPs.

引用

页数：15

共 161 条

[61] A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response [J].

Huarte, Maite ;

Guttman, Mitchell ;

Feldser, David ;

Garber, Manuel ;

Koziol, Magdalena J. ;

Kenzelmann-Broz, Daniela ;

Khalil, Ahmad M. ;

Zuk, Or ;

Amit, Ido ;

Rabani, Michal ;

Attardi, Laura D. ;

Regev, Aviv ;

Lander, Eric S. ;

Jacks, Tyler ;

Rinn, John L. .

CELL, 2010, 142 (03) :409-419

[62] RETRACTED: Linc-ROR targets FGF2 to regulate HASMC proliferation and migration via sponging miR-195-5p (Retracted Article) [J].

Ji, Zheng ;

Chi, Jufang ;

Sun, He ;

Ru, Ao ;

Ni, Tingjuan ;

Zhang, Jie ;

Jiang, Fengchun ;

Lv, Haitao ;

Peng, Fang ;

Guo, Hangyuan ;

Chen, Yi .

GENE, 2020, 725

[63] microRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator [J].

Jiang, Huajun ;

Zhang, Jin ;

Du, Yu ;

Jia, Xiaojian ;

Yang, Fan ;

Si, Shuyi ;

Wang, Li ;

Hong, Bin .

ATHEROSCLEROSIS, 2015, 243 (02) :523-532

[64] Diversity of macrophage phenotypes and responses in atherosclerosis [J].

Jinnouchi, Hiroyuki ;

Guo, Liang ;

Sakamoto, Atsushi ;

Torii, Sho ;

Sato, Yu ;

Cornelissen, Anne ;

Kuntz, Salome ;

Paek, Ka Hyun ;

Fernandez, Raquel ;

Fuller, Daniela ;

Gadhoke, Neel ;

Surve, Dipti ;

Romero, Maria ;

Kolodgie, Frank D. ;

Virmani, Renu ;

Finn, Aloke V. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2020, 77 (10) :1919-1932

[65] RNA-Binding Proteins as Important Regulators of Long Non-Coding RNAs in Cancer [J].

Jonas, Katharina ;

Calin, George A. ;

Pichler, Martin .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)

[66] Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs [J].

Kapusta, Aurelie ;

Kronenberg, Zev ;

Lynch, Vincent J. ;

Zhuo, Xiaoyu ;

Ramsay, LeeAnn ;

Bourque, Guillaume ;

Yandell, Mark ;

Feschotte, Cedric .

PLOS GENETICS, 2013, 9 (04)

[67] Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA [J].

Khyzha, Nadiya ;

Khor, Melvin ;

DiStefano, Peter V. ;

Wang, Liangxi ;

Matic, Ljubica ;

Hedin, Ulf ;

Wilson, Michael D. ;

Maegdefessel, Lars ;

Fish, Jason E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (33) :16410-16419

[68] Vascular Endothelial Cell Biology: An Update [J].

Krueger-Genge, Anne ;

Blocki, Anna ;

Franke, Ralf-Peter ;

Jung, Friedrich .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (18)

[69] The tandem zinc finger RNA binding domain of members of the tristetraprolin protein family [J].

Lai, Wi S. ;

Wells, Melissa L. ;

Perera, Lalith ;

Blackshear, Perry J. .

WILEY INTERDISCIPLINARY REVIEWS-RNA, 2019, 10 (04)

[70] Compartmentalization of hnRNP-K during cell cycle progression and its interaction with calponin in the cytoplasm [J].

Laury-Kleintop, LD ;

Tresini, M ;

Hammond, O .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2005, 95 (05) :1042-1056

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