The first transition metal-ligand complex-catalyzed regioselective and stereoselective aminohalogenation of cinnamic esters

被引：87

作者：

Wei, HX ^{[1
]}

Kim, SH ^{[1
]}

Li, GG ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

TETRAHEDRON | 2001年 / 57卷 / 18期

基金：

美国国家卫生研究院;

关键词：

haloamine; aminohalogenation; catalysis;

D O I：

10.1016/S0040-4020(01)00228-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transition metal-ligand complex-catalyzed regio- and stereoselective aminohalogenation of cinnamic esters has been developed using p-TsNCl2 as the nitrogen and chlorine sources. Dichloro-(1,10-phenanthroline)-palladium (II) as the catalyst can be handled very conveniently due to its property of less hygroscopic as compared with other aminohalogenation catalysts. The reaction is suggested to proceed through the mechanism involving N-tosyl N-chloro aziridinium intermediate. Eight examples are presented with modest to good yields (56-82%) and excellent stereoselectivity (> 10:1). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3869 / 3873

页数：5

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