SMAD4 and its role in pancreatic cancer

被引：84
作者：
Xia, Xiang [1 ]
Wu, Weidong [1 ]
Huang, Chen [1 ]
Cen, Gang [1 ]
Jiang, Tao [1 ]
Cao, Jun [1 ]
Huang, Kejian [1 ]
Qiu, Zhengjun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
来源：
TUMOR BIOLOGY | 2015年 / 36卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Pancreatic cancer; TGF-beta signaling pathway; Loss of SMAD4; Prognosis; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; PAPILLARY-MUCINOUS NEOPLASMS; DUCTAL ADENOCARCINOMA; INTRAEPITHELIAL NEOPLASIA; CELL-LINES; DPC4; GENE; IN-VITRO; K-RAS; DPC4/SMAD4; EXPRESSION;
D O I：
10.1007/s13277-014-2883-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor-beta (TGF-beta) regulates cell functions and has key roles in pancreatic cancer development. SMAD4, as one of the Smads family of signal transducer from TGF-beta, mediates pancreatic cell proliferation and apoptosis and is specifically inactivated in half of advanced pancreatic cancers. In recent years, many advances concerning SMAD4 had tried to unravel the complex signaling mechanisms of TGF-beta and its dual role of tumor-suppressive and tumor-promoting efforts in pancreatic cancer initiation and progression through SMAD4-dependent TGF-beta signaling and SMAD4-independent TGF-beta signaling pathways. Meanwhile, its potential prognostic value based on immunohistochemical expression in surgical sample was variably reported by several studies and short of a systematic analysis. This review aimed to discuss the structure, functions, and regulation of this principal protein and its effects in determining the progression and prognosis of pancreatic cancer.
引用
收藏
页码：111 / 119
页数：9
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