Parkinson's disease diagnosis using convolutional neural networks and figure-copying tasks

被引:30
作者
Alissa, Mohamad [1 ]
Lones, Michael A. [2 ]
Cosgrove, Jeremy [3 ]
Alty, Jane E. [4 ,5 ]
Jamieson, Stuart [3 ]
Smith, Stephen L. [6 ]
Vallejo, Marta [7 ]
机构
[1] Napier Univ, Sch Comp, Edinburgh, Midlothian, Scotland
[2] Heriot Watt Univ, Sch Math & Comp Sci, Edinburgh, Midlothian, Scotland
[3] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England
[4] Univ Tasmania, Wicking Dementia Ctr, Hobart, Tas, Australia
[5] Univ Tasmania, Sch Med, Hobart, Tas, Australia
[6] Univ York, Dept Elect Engn, York, N Yorkshire, England
[7] Heriot Watt Univ, Sch Engn & Phys Sci, Edinburgh, Midlothian, Scotland
关键词
Convolutional neural networks; Parkinson's disease; Drawing tasks; Deep learning classifier; Diagnosis; HANDWRITING ANALYSIS; ALZHEIMERS-DISEASE; CLASSIFICATION; MOVEMENT; MICROGRAPHIA; DISORDERS; ACCURACY; CUBE;
D O I
10.1007/s00521-021-06469-7
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Parkinson's disease (PD) is a progressive neurodegenerative disorder that causes abnormal movements and an array of other symptoms. An accurate PD diagnosis can be a challenging task as the signs and symptoms, particularly at an early stage, can be similar to other medical conditions or the physiological changes of normal ageing. This work aims to contribute to the PD diagnosis process by using a convolutional neural network, a type of deep neural network architecture, to differentiate between healthy controls and PD patients. Our approach focuses on discovering deviations in patient's movements with the use of drawing tasks. In addition, this work explores which of two drawing tasks, wire cube or spiral pentagon, are more effective in the discrimination process. With 93.5% accuracy, our convolutional classifier, trained with images of the pentagon drawing task and augmentation techniques, can be used as an objective method to discriminate PD from healthy controls. Our compact model has the potential to be developed into an offline real-time automated single-task diagnostic tool, which can be easily deployed within a clinical setting.
引用
收藏
页码:1433 / 1453
页数:21
相关论文
共 88 条
[31]  
Glorot X., 2010, JMLR WORKSHOP C P, P249
[32]   The Unified Parkinson's Disease Rating Scale (UPDRS): Status and recommendations [J].
Goetz, CG ;
Poewe, W ;
Rascol, O ;
Sampaio, C ;
Stebbins, GT ;
Fahn, S ;
Lang, AE ;
Martinez-Martin, P ;
Tilley, B ;
Van Hilten, B ;
Kleczka, C ;
Seidl, L .
MOVEMENT DISORDERS, 2003, 18 (07) :738-750
[33]  
Goodfellow I, 2016, ADAPT COMPUT MACH LE, P1
[34]   Deep Learning in Medical Imaging: Overview and Future Promise of an Exciting New Technique [J].
Greenspan, Hayit ;
van Ginneken, Bram ;
Summers, Ronald M. .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2016, 35 (05) :1153-1159
[35]  
He K, 2016, IEEE C COMP VIS PATT, DOI [10.1109/CVPR.2016.90, DOI 10.1109/CVPR.2016.90, 10.48550/arXiv.1512.03385, DOI 10.48550/ARXIV.1512.03385]
[36]   Deep Neural Networks for Acoustic Modeling in Speech Recognition [J].
Hinton, Geoffrey ;
Deng, Li ;
Yu, Dong ;
Dahl, George E. ;
Mohamed, Abdel-rahman ;
Jaitly, Navdeep ;
Senior, Andrew ;
Vanhoucke, Vincent ;
Patrick Nguyen ;
Sainath, Tara N. ;
Kingsbury, Brian .
IEEE SIGNAL PROCESSING MAGAZINE, 2012, 29 (06) :82-97
[37]  
Hollmen J, 2000, WIT T INFORM COMMUN
[38]   A CLINICOPATHOLOGICAL STUDY OF 100 CASES OF PARKINSONS-DISEASE [J].
HUGHES, AJ ;
DANIEL, SE ;
BLANKSON, S ;
LEES, AJ .
ARCHIVES OF NEUROLOGY, 1993, 50 (02) :140-148
[39]   The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service [J].
Hughes, AJ ;
Daniel, SE ;
Ben-Shlomo, Y ;
Lees, AJ .
BRAIN, 2002, 125 :861-870
[40]   ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].
HUGHES, AJ ;
DANIEL, SE ;
KILFORD, L ;
LEES, AJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184