KID-1, a protein kinase induced by depolarization in brain

被引：87

作者：

Feldman, JD

Vician, L

Crispino, M

Tocco, G

Marcheselli, VL

Bazan, NG

Baudry, M

Herschman, HR

机构：

[1] Univ Calif Los Angeles, Ctr Hlth Sci, Inst Mol Biol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Ctr Hlth Sci, Dept Pediat, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Ctr Hlth Sci, Dept Biol Chem, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Ctr Hlth Sci, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[5] Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA

[6] Louisiana State Univ, Med Ctr, Ctr Neurosci, New Orleans, LA 70112 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1998年 / 273卷 / 26期

关键词：

D O I：

10.1074/jbc.273.26.16535

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane depolarization leads to changes in gene expression that modulate neuronal plasticity. Using representational difference analysis, we have identified a previously undiscovered cDNA,KID-1 (kinase induced by depolarization), that is induced by membrane depolarization or forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells, KID-1 is an immediate early gene that shares a high degree of sequence similarity with the family of PIM-1 serine/threonine protein kinases, Recombinant KID-1 fusion protein is able to catalyze both histone phosphorylation and autophosphorylation, KID-1 mRNA is present in a number of unstimulated tissues, including brain. In response to kainic acid and electroconvulsive shock-induced seizures, KID-1 is induced in specific regions of the hippocampus and cortex.

引用

页码：16535 / 16543

页数：9

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