Labdane diterpenes with a new oxidation pattern from the marine pulmonate Trimusculus peruvianus

被引：14

作者：

Díaz-Marrero, AR

Dorta, E

Cueto, M

Rovirosa, J

San-Martín, A

Loyola, A

Darias, J

机构：

[1] CSIC, Inst Prod Nat & Agrobiol, San Cristobal la Laguna 38206, Tenerife, Spain

[2] Univ Chile, Fac Ciencias, Dept Quim, Santiago, Chile

[3] Univ Antofagasta, Fac Ciencias, Dept Quim, Antofagasta, Chile

来源：

TETRAHEDRON | 2003年 / 59卷 / 26期

关键词：

labdane diterpenes; pulmonate; carcinoma;

D O I：

10.1016/S0040-4020(03)00731-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new labdane diterpenes, 1-4, with an unusual oxidation pattern have been isolated from the marine pulmonate Trimusculus peruvianus. The structure and stereochemistry of these compounds were determined by spectroscopic data and chemical transformations. The absolute stereochemistry of 4 was assigned by application of the modified Mosher method. These compounds exhibit in vitro moderate cytotoxic activity against human colon carcinoma cell lines. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4805 / 4809

页数：5

共 7 条

[1] Labdane diterpenes from the South African marine pulmonate Trimusculus costatus
Gray, CA
Davies-Coleman, MT
McQuaid, C
NATURAL PRODUCT LETTERS, 1998, 12 (01): : 47 - 53
[2] Mantle defensive response of marine pulmonate Trimusculus peruvianus
San-Martin, A.
Rovirosa, J.
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Ampuero, J.
JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY, 2009, 376 (01) : 43 - 47
[3] New labdane diterpenes from Solidago canadensis
Wangensteen, Helle
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Rise, Frode
Halvorsen, Trine G.
Malterud, Karl E.
NATURAL PRODUCT RESEARCH, 2012, 26 (14) : 1348 - 1354
[4] New labdane diterpenes from Leonurus cardiaca
Agnihotri, Vijai K.
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Khan, Ikhlas A.
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PLANTA MEDICA, 2008, 74 (10) : 1288 - 1290
[5] Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (24) : 7544 - 7548
[6] Two New ent-Labdane Diterpenes from the Roots of Euphorbia yinshanica
Ben-Yin Zhang
Heng-Xia Yin
De-Jun Zhang
Chemistry of Natural Compounds, 2017, 53 : 295 - 298
[7] New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production
Li, Yu-Peng
Zhao, Si-Meng
Xu, Jun-Ju
Zeng, Guang-Zhi
Li, Yan
Tan, Ning-Hua
Yang, Ye
NATURAL PRODUCT RESEARCH, 2016, 30 (23) : 2669 - 2674

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