Reactive oxygen radicals in signaling and damage in the ischemic brain

被引：1386

作者：

Chan, PH

机构：

[1] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Neurosci Program, Stanford, CA 94305 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2001年 / 21卷 / 01期

关键词：

reactive oxygen species; free radicals; apoptosis; cerebral ischemia; transgenic and knockout mice; oxidative stress signaling;

D O I：

10.1097/00004647-200101000-00002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reactive oxygen species have been implicated in brain injury after ischemic stroke. These oxidants can react and damage the cellular macromolecules by virtue of the reactivity that leads to cell injury and necrosis. Oxidants an also media- tors in signaling involving mitnchondria, DNA repair enzymes, and transcription factors that may lead to apoptosis after cerebral ischemia. Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury.

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页码：2 / 14

页数：13

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