The biology underlying molecular imaging in oncology: from genome to anatome and back again

被引：141

作者：

Gillies, R. J. ^{[1
]}

Anderson, A. R. ^{[1
]}

Gatenby, R. A. ^{[1
]}

Morse, D. L. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33602 USA

来源：

CLINICAL RADIOLOGY | 2010年 / 65卷 / 07期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE; SPATIAL HETEROGENEITY; GLIOBLASTOMA-MULTIFORME; REGIONAL EXPRESSION; DIFFUSION MRI; TUMOR; CANCER; MICROENVIRONMENT; METABOLISM;

D O I：

10.1016/j.crad.2010.04.005

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Cancers are complex, evolving, multiscale ecosystems that are characterized by profound spatial and temporal heterogeneity. The interactions in cancer are non-linear in that small changes in one variable can have large changes on another. These multiple interacting phenotypes and spatial scales can best be understood with appropriate mathematical and computational models. Imaging is central to this investigation because it can non-destructively and longitudinally characterize spatial variations in the tumour phenotype and environment so that the system dynamics over time can be captured quantitatively. (C) 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：517 / 521

页数：5

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