Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin-angiotensin system in inflammation

被引：13

作者：

Chappell, Mark C. ^{[1
]}

机构：

[1] Wake Forest Sch Med, Hypertens & Vasc Dis Ctr, Winston Salem, NC 27015 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷 / 03期

关键词：

HYPERTENSION;

D O I：

10.1186/ar3052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Traditionally viewed as important in the regulation of blood pressure, the renin-angiotensin system - and specifically the angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-AT(1) receptor axis - may play a prominent role to promote inflammation and fibrosis. ACE2, a new component of the renin-angiotensin system, has emerged as a key enzyme that selectively degrades Ang II and generates Ang-(1-7), a bioactive peptide with anti-inflammatory and anti-fibrotic actions. Takahashi and colleagues demonstrate circulating titers of inhibitory autoantibodies against ACE2 in patients with systemic sclerosis. The current study reveals a potentially novel mechanism to attenuate the catalytic activity of ACE2, thereby promoting the actions of Ang II.

引用

页数：2

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