Background: Cervical cancer is a worldwide public health concern, and approximately 85% of deaths occurs in developing countries. Thus study is designed to assess knowledge, attitude, and practice towards cervical cancer screening in Wolaita Zone, Southern Ethiopia. Methods: We conducted a facility-based cross-sectional study. In this research, we used a multi-stage sampling procedure to select 520 participants. Information on socio-demographics, knowledge, attitude, and cervical cancer screening related questionnaires were collected using face-to-face interviews. Data were entered and cleaned in Epi-Data version 3.1 and exported to SPSS version 20 for analysis. For the analysis, we used logistic regression along with odds ratios and 95% confidence intervals. The statistical significance was determined by p<0.05. Results: Approximately 154 (43.1%) of women had good knowledge, 235 (45.5%) had a favorable attitude, and nearly a quarter (118; 22.9%) had been screened for cervical cancer. Women 30-34 years [AOR=3.02, 95% CI: 1.11, 8.24), women with degree/diploma level of education [AOR=7.3, 95% CI 2.53-21.01), and having sourced information from a health professional [AOR=2.3, 95% CI: 1.27-4.17) were associated with good knowledge of cervical cancer screening. Being single [AOR=3.47, 95% CI: 1.03-11.75] and good knowledge of cervical cancer [AOR=4.76, 95%:2.65-8.57) were significant predictors of a positive attitude towards cervical cancer screening. Women who knew cervical cancer patients [AOR=2.47, 95% (1.37-4.44)] and high monthly income [AOR=3.8, 95% CI: 1.86-7.77] were associated with good practice related to cervical cancer screening. Conclusion: Knowledge, attitude, and practice towards cervical cancer screening were shallow. The concerned body should aggressively disseminate information on cervical cancer screening, improve the economic status of women, and provide counseling about cervical cancer during health care delivery visits.
