Preparation and use of MeO-PEG-supported chiral diphosphine ligands: soluble polymer-supported catalysts for asymmetric hydrogenation

被引：58

作者：

Fan, QH ^{[1
]}

Deng, GJ

Lin, CC

Chan, ASC

机构：

[1] Chinese Acad Sci, Inst Chem, LMRSS, Ctr Mol Sci, Beijing 100080, Peoples R China

[2] Hong Kong Polytech Univ, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(01)00210-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two new chiral MeO-PEG-supported (R)-BINAP and (3R,4R)-Pyrphos ligands were synthesized and employed in the Ru(II)- and Rh(I)-catalyzed asymmetric hydrogenation of 2-(6 ' -methoxy-2 ' -naphthyl)propenoic acid 5 and prochiral enamides 10. The results showed that these new soluble polymeric catalysts exhibited high catalytic activity and enantioselectivity. Enantiomeric excesses (e.e.s) in the ranges 90-96% and 86-96% were achieved in the hydrogenation of 5 and 10, respectively. Furthermore, these catalysts could he recovered easily and the recycled catalysts were shown to maintain their efficiency in subsequent reactions. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1241 / 1247

页数：7

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