Blastic Plasmacytoid Dendritic Cell Neoplasm: A Rare Case Report with Literature Review

被引：0

作者：

Nikita, Oza ^{[1
]}

Rathnam, Krishnakumar ^{[2
]}

Sumeet, Gujral ^{[3
]}

Honey, Susan R. ^{[2
]}

Saju, S., V ^{[2
]}

Shubhada, Kane ^{[1
]}

机构：

[1] SRL Diagnost Ctr Excellence, Dept Histopathol, SV Rd, Mumbai 400016, Maharashtra, India

[2] Meenakshi Mission Hosp & Res Ctr, Dept Med Oncol, Madurai, Tamil Nadu, India

[3] Tata Mem Hosp, Dept Pathol, Mumbai, Maharashtra, India

来源：

INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY | 2021年 / 42卷 / 05期

关键词：

blastic plasmacytoid dendritic cell neoplasm; chemotherapy; stem cell therapy; targeted therapy; LEUKEMIC PRESENTATION; HEMATOLOGICAL NEOPLASMS; ORGANIZATION; THERAPY; SERIES; TUMOR; SKIN;

D O I：

10.1055/s-0041-1736432

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm for which there are no effective therapies. We present a 70-year-old male patient with multiple reddish painless, nonpruritic, and nonpedunculated nodules over the trunk, forearm, and thighs for a duration of 3 months. The nodules measured 0.5 to 2 cm in diameter. The peripheral smear findings were within normal limits. Excision biopsy was performed. Histomorphology and immunohistochemistry (CD123, CD 56, CD4, HLA-DR, CD43, and CD68) confirmed the diagnosis of BPDCN. Findings of marrow aspiration, biopsy and imaging studies were within normal limits. Patient demonstrated a good response with complete disappearance of all nodules by initial 2 weeks of therapy with a modified Berlin-Frankfurt-Munster (BFM) acute lymphoblastic leukemia (ALL) protocol and has completed 8 doses (LSAP [lincosamides, streptogramins A and pleuromutilins chemotherapy], 5,000 units/m (2) ). The patient tolerated protocol extremely well.

引用

页码：496 / 500

页数：5

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