Genetic Evidence That DNA Methyltransferase DRM2 Has a Direct Catalytic Role in RNA-Directed DNA Methylation in Arabidopsis thaliana

被引：45

作者：

Naumann, Ulf ^{[1
]}

Daxinger, Lucia ^{[1
]}

Kanno, Tatsuo ^{[1
]}

Eun, Changho ^{[1
]}

Long, Quan ^{[1
]}

Lorkovic, Zdravko J. ^{[1
]}

Matzke, Marjori ^{[1
]}

Matzke, Antonius J. M. ^{[1
]}

机构：

[1] Austrian Acad Sci, Gregor Mendel Inst, A-1030 Vienna, Austria

来源：

GENETICS | 2011年 / 187卷 / 03期

关键词：

PROTEIN;

D O I：

10.1534/genetics.110.125401

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RNA-directed DNA methylation (RdDM) is a small RNA-mediated epigenetic modification in plants. We report here the identification of DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) in a forward screen for mutants defective in RdDM in Arabidopsis thaliana. The finding of a mutation in the presumptive active site argues in favor of direct catalytic activity for DRM2.

引用

页码：977 / 979

页数：3

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