Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer's disease

被引：59

作者：

Dey, Mangaldeep ^{[1
]}

Singh, Rakesh Kumar ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Raebareli,Transit Campus,Bijnour Sisendi Rd, Lucknow 226002, Uttar Pradesh, India

来源：

PHARMACOLOGICAL REPORTS | 2022年 / 74卷 / 03期

关键词：

Alzheimer's disease; Neuroinflammation; Calcium dyshomeostasis; Chelation therapy; Neurodegeneration; AMYLOID PRECURSOR PROTEIN; INDUCED OXIDATIVE STRESS; NEUROPROTECTIVE ROLE; COGNITIVE DECLINE; RAT MODEL; MITOCHONDRIAL DYSFUNCTION; DIALYSIS ENCEPHALOPATHY; LIPID-PEROXIDATION; INDUCED APOPTOSIS; IRON HOMEOSTASIS;

D O I：

10.1007/s43440-022-00353-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aluminium is one of the most widely distributed elements of the Earth's crust. Its routine use has resulted in excessive human exposure and due to the potential neurotoxic effects has attained a huge interest in recent years. Despite its ubiquitous abundance, aluminium has no crucial biological functions in the human body. Oxidative stress and neuroinflammatory effects are attributed to its neurotoxic manifestations implicated in Alzheimer's disease. In this review, we have discussed the neuroinflammatory and neurodegenerative events in the brain induced by aluminium exposure. We have highlighted the neurotoxic events caused by aluminium, such as oxidative stress, apoptosis, inflammatory events, calcium dyshomeostasis, A beta deposition, and neurofibrillary tangle formation in the brain. In addition, the protective measures needed for prevention of aluminium-induced neuronal dysregulations have also been discussed.

引用

页码：439 / 450

页数：12

共 103 条

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