Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease

被引：12

作者：

Miyake, Teruki ^{[1
]}

Matsuura, Bunzo ^{[2
]}

Furukawa, Shinya ^{[3
]}

Todo, Yasuhiko ^{[1
]}

Yamamoto, Shin ^{[1
]}

Yoshida, Osamu ^{[1
]}

Imai, Yusuke ^{[1
]}

Watanabe, Takao ^{[1
]}

Yamamoto, Yasunori ^{[1
]}

Hirooka, Masashi ^{[1
]}

Tokumoto, Yoshio ^{[1
]}

Kumagi, Teru ^{[1
]}

Abe, Masanori ^{[1
]}

Seike, Hirotaka ^{[4
]}

Miyauchi, Shozo ^{[4
]}

Hiasa, Yoichi ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Matsuyama, Ehime, Japan

[2] Ehime Univ, Grad Sch Med, Dept Lifestyle Related Med, Matsuyama, Ehime, Japan

[3] Ehime Univ, Grad Sch Med, Dept Publ Hlth, Matsuyama, Ehime, Japan

[4] Shiritsu Uwajima Hosp, Dept Internal Med, Uwajima, Ehime, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 15期

关键词：

nonalcoholic steatohepatitis; hepatic steatosis; Graves' disease; hyperthyroidism; FATTY LIVER-DISEASE; FREE THYROXINE LEVELS; HEPATIC STEATOSIS; MORBID-OBESITY; HYPOTHYROIDISM; POPULATION; RATS; METABOLISM; AGONIST;

D O I：

10.2169/internalmedicine.55.6640

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

3,5,3'-triiodo-L-thyronine regulates the glucose metabolism, lipid metabolism, and hepatic steatosis. Several groups have shown the relationships between hypothyroidism and nonalcoholic fatty liver and hypothyroidism and nonalcoholic steatohepatitis (NASH). However, the effect of hyperthyroidism on NASH has not yet been investigated. We herein report effects of thyroid hormone on the pathological condition of NASH in a patient with NASH complicated by Graves' disease. In our case, the liver enzyme level improved with the increasing thyroid hormone level; however, the liver enzyme level was aggravated with the improving thyroid hormone level. Therefore, hyperthyroidism may improve the pathological condition of NASH.

引用

页码：2019 / 2023

页数：5

共 23 条

[1] The natural history of nonalcoholic fatty liver disease: A population-based cohort study
Adams, LA
Lymp, JF
St Sauver, J
Sanderson, SO
Lindor, KD
Feldstein, A
Angulo, P
[J]. GASTROENTEROLOGY, 2005, 129 (01) : 113 - 121
[2] Nonalcoholic fatty liver disease
Brunt, Elizabeth M.
Wong, Vincent W. -S.
Nobili, Valerio
Day, Christopher P.
Sookoian, Silvia
Maher, Jacquelyn J.
Bugianesi, Elisabetta
Sirlin, Claude B.
Neuschwander-Tetri, BrentA.
Rinella, Mary E.
[J]. NATURE REVIEWS DISEASE PRIMERS, 2015, 1
[3] Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
[4] Reduction of Hepatic Steatosis in Rats and Mice After Treatment with a Liver-Targeted Thyroid Hormone Receptor Agonist
Cable, Edward E.
Finn, Patricia D.
Stebbins, Jeffrey W.
Hou, Jinzhao
Ito, Bruce R.
van Poelje, Paul D.
Linemeyer, David L.
Erion, Mark D.
[J]. HEPATOLOGY, 2009, 49 (02) : 407 - 417
[5] Is nonalcoholic steatohepatitis associated with a high-though-normal thyroid stimulating hormone level and lower cholesterol levels?
Carulli, Lucia
Ballestri, Stefano
Lonardo, Amedeo
Lami, Francesca
Violi, Enrico
Losi, Luisa
Bonilauri, Lisa
Verrone, Anna Maria
Odoardi, Maria Rosaria
Scaglioni, Federica
Bertolotti, Marco
Loria, Paola
[J]. INTERNAL AND EMERGENCY MEDICINE, 2013, 8 (04) : 297 - 305
[6] Non-alcoholic fatty liver disease across the spectrum of hypothyroidism
Chung, Goh Eun
Kim, Donghee
Kim, Won
Yim, Jeong Yoon
Park, Min Jung
Kim, Yoon Jun
Yoon, Jung-Hwan
Lee, Hyo-Suk
[J]. JOURNAL OF HEPATOLOGY, 2012, 57 (01) : 150 - 156
[7] Mazo Daniel Ferraz de Campos, 2011, Arq. Gastroenterol., V48, P186, DOI 10.1590/S0004-28032011000300006
[8] Eshraghian A, 2013, ARCH IRAN MED, V16, P584, DOI 0131610/AIM.007
[9] Nonalcoholic fatty liver disease and vascular disease: State-of-the-art
Fargion, Silvia
Porzio, Marianna
Fracanzani, Anna Ludovica
[J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (37) : 13306 - 13324
[10] Factors affecting drug-induced liver injury: antithyroid drugs as instances
Heidari, Reza
Niknahad, Hossein
Jamshidzadeh, Akram
Abdoli, Narges
[J]. CLINICAL AND MOLECULAR HEPATOLOGY, 2014, 20 (03) : 237 - 248

← 1 2 3 →