Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

被引：394

作者：

Niemeijer, A. N. ^{[1
]}

Leung, D. ^{[2
]}

Huisman, M. C. ^{[3
]}

Bahce, I ^{[1
]}

Hoekstra, O. S. ^{[3
]}

van Dongen, G. A. M. S. ^{[3
]}

Boellaard, R. ^{[3
]}

Du, S. ^{[2
]}

Hayes, W. ^{[2
]}

Smith, R. ^{[2
]}

Windhorst, A. D. ^{[3
]}

Hendrikse, N. H. ^{[3
]}

Poot, A. ^{[3
]}

Vugts, D. J. ^{[3
]}

Thunnissen, E. ^{[4
]}

Morin, P. ^{[2
]}

Lipovsek, D. ^{[2
]}

Donnelly, D. J. ^{[2
]}

Bonacorsi, S. J. ^{[2
]}

Velasquez, L. M. ^{[2
]}

de Gruijl, T. D. ^{[5
]}

Smit, E. F. ^{[6
]}

de Langen, A. J. ^{[1
,6
]}

机构：

[1] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Pulm Dis, Amsterdam UMC, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[2] Bristol Myers Squibb Res & Dev, Route 206 & Prov Line Rd, Princeton, NJ 08543 USA

[3] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Pathol, Amsterdam UMC, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam UMC, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[6] Netherlands Canc Inst, Dept Thorac Oncol, Plesmanlaan 2, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

P-ISOTHIOCYANATOBENZYL-DESFERRIOXAMINE; MONOCLONAL-ANTIBODIES; BIFUNCTIONAL CHELATE; IMMUNO-PET; EXPRESSION; ZIRCONIUM-89; DOCETAXEL; NSCLC;

D O I：

10.1038/s41467-018-07131-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L) 1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L) 1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.

引用

页数：5

共 24 条

[1] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[2] Radiosynthesis and preclinical PET evaluation of 89Zr-nivolumab (BMS-936558) in healthy non-human primates [J].

Cole, Erin L. ;

Kim, Joonyoung ;

Donnelly, David J. ;

Smith, R. Adam ;

Cohen, Daniel ;

Lafont, Virginie ;

Morin, Paul E. ;

Huang, Richard Y. -C. ;

Chow, Patrick L. ;

Hayes, Wendy ;

Bonacorsi, Samuel, Jr. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (20) :5407-5414

[3] Reproducibility of Tumor Perfusion Measurements Using 15O-Labeled Water and PET [J].

de Langen, Adrianus J. ;

Lubberink, Mark ;

Boellaard, Ronald ;

Spreeuwenberg, Marieke D. ;

Smit, Egbert F. ;

Hoekstra, Otto S. ;

Lammertsma, Adriaan A. .

JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (11) :1763-1768

[4] Synthesis and Biologic Evaluation of a Novel 18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression [J].

Donnelly, David J. ;

Smith, R. Adam ;

Morin, Paul ;

Lipovsek, Dasa ;

Gokemeijer, Jochem ;

Cohen, Daniel ;

Lafont, Virginie ;

Tran, Tritin ;

Cole, Erin L. ;

Wright, Martin ;

Kim, Joonyoung ;

Pena, Adrienne ;

Kukral, Daniel ;

Dischino, Douglas D. ;

Chow, Patrick ;

Gan, Jinping ;

Adelakun, Olufemi ;

Wang, Xi-Tao ;

Cao, Kai ;

Leung, David ;

Bonacorsi, Samuel J., Jr. ;

Hayes, Wendy .

JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (03) :529-535

[5] New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) [J].

Eisenhauer, E. A. ;

Therasse, P. ;

Bogaerts, J. ;

Schwartz, L. H. ;

Sargent, D. ;

Ford, R. ;

Dancey, J. ;

Arbuck, S. ;

Gwyther, S. ;

Mooney, M. ;

Rubinstein, L. ;

Shankar, L. ;

Dodd, L. ;

Kaplan, R. ;

Lacombe, D. ;

Verweij, J. .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (02) :228-247

[6] Heterogeneous expression of PD-L1 in pulmonary squamous cell carcinoma and adenocarcinoma: implications for assessment by small biopsy [J].

Gniadek, Thomas J. ;

Li, Qing Kay ;

Tully, Ellen ;

Chatterjee, Samit ;

Nimmagadda, Sridhar ;

Gabrielson, Edward .

MODERN PATHOLOGY, 2017, 30 (04) :530-538

[7] NFATc1 Promotes Antitumoral Effector Functions and Memory CD8+ T-cell Differentiation during Non-Small Cell Lung Cancer Development [J].

Heim, Lisanne ;

Friedrich, Juliane ;

Engelhardt, Marina ;

Trufa, Denis I. ;

Geppert, Carol I. ;

Rieker, Ralf J. ;

Sirbu, Horia ;

Finotto, Susetta .

CANCER RESEARCH, 2018, 78 (13) :3619-3633

[8] Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial [J].

Herbst, Roy S. ;

Baas, Paul ;

Kim, Dong-Wan ;

Felip, Enriqueta ;

Perez-Gracia, Jose L. ;

Han, Ji-Youn ;

Molina, Julian ;

Kim, Joo-Hang ;

Arvis, Catherine Dubos ;

Ahn, Myung-Ju ;

Majem, Margarita ;

Fidler, Mary J. ;

de Castro, Gilberto, Jr. ;

Garrido, Marcelo ;

Lubiniecki, Gregory M. ;

Shentu, Yue ;

Im, Ellie ;

Dolled-Filhart, Marisa ;

Garon, Edward B. .

LANCET, 2016, 387 (10027) :1540-1550

[9] Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients [J].

Herbst, Roy S. ;

Soria, Jean-Charles ;

Kowanetz, Marcin ;

Fine, Gregg D. ;

Hamid, Omid ;

Gordon, Michael S. ;

Sosman, Jeffery A. ;

McDermott, David F. ;

Powderly, John D. ;

Gettinger, Scott N. ;

Kohrt, Holbrook E. K. ;

Horn, Leora ;

Lawrence, Donald P. ;

Rost, Sandra ;

Leabman, Maya ;

Xiao, Yuanyuan ;

Mokatrin, Ahmad ;

Koeppen, Hartmut ;

Hegde, Priti S. ;

Mellman, Ira ;

Chen, Daniel S. ;

Hodi, F. Stephen .

NATURE, 2014, 515 (7528) :563-+

[10] Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies [J].

Ilie, M. ;

Long-Mira, E. ;

Bence, C. ;

Butori, C. ;

Lassalle, S. ;

Bouhlel, L. ;

Fazzalari, L. ;

Zahaf, K. ;

Lalvee, S. ;

Washetine, K. ;

Mouroux, J. ;

Venissac, N. ;

Poudenx, M. ;

Otto, J. ;

Sabourin, J. C. ;

Marquette, C. H. ;

Hofman, V. ;

Hofman, P. .

ANNALS OF ONCOLOGY, 2016, 27 (01) :147-153

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