Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

被引：32

作者：

Kirkham, Steven ^{[1
]}

Castelletto, Valeria ^{[1
]}

Hamley, Ian William ^{[1
]}

Inoue, Katsuaki ^{[2
]}

Rambo, Robert ^{[2
]}

Reza, Mehedi ^{[3
]}

Ruokolainen, Janne ^{[3
]}

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

[2] Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0DE, Oxon, England

[3] Aalto Univ, Dept Appl Phys, POB 15100, Aalto 00076, Finland

来源：

CHEMPHYSCHEM | 2016年 / 17卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

antimicrobial peptides; lipopeptide; micelles; secondary structure; self-assembly; ANTIBIOTIC DAPTOMYCIN; NANOSTRUCTURES; FLUORESCENCE; MEMBRANES; LY146032;

D O I：

10.1002/cphc.201600308

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.

引用

页码：2118 / 2122

页数：5

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