Mechanisms of cancer dissemination along nerves

被引:244
作者
Amit, Moran [1 ]
Na'ara, Shorook [1 ]
Gil, Ziv [1 ]
机构
[1] Technion Israel Inst Technol, Lab Appl Canc Res, Dept Otolaryngol Head & Neck Surg, Head & Neck Ctr,Clin Res Inst Rambam,Rappaport In, Rambam Healthcare Campus,Haalia St 8, Haifa, Israel
基金
以色列科学基金会;
关键词
PANCREATIC DUCTAL ADENOCARCINOMA; SQUAMOUS-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; PROMOTES PERINEURAL INVASION; ADENOID CYSTIC CARCINOMA; TYROSINE KINASE RECEPTOR; ADHESION MOLECULE L1; PROSTATE-CANCER; NERVOUS-SYSTEM; NEURAL INVASION;
D O I
10.1038/nrc.2016.38
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The local extension of cancer cells along nerves is a frequent clinical finding for various tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; however, recent animal models and human studies have revealed that cancer cells have an innate ability to actively migrate along axons in a mechanism called neural tracking. The tendency of cancer cells to track along nerves is supported by various cell types in the perineural niche that secrete multiple growth factors and chemokines. We propose that the perineural niche should be considered part of the tumour microenvironment, describe the molecular cues that facilitate neural tracking and suggest methods for its inhibition.
引用
收藏
页码:399 / 408
页数:10
相关论文
共 145 条
[1]   Consensus transcriptome signature of perineural invasion in pancreatic carcinoma [J].
Abiatari, Ivane ;
DeOliveira, Tiago ;
Kerkadze, Vachtang ;
Schwager, Christian ;
Esposito, Irene ;
Giese, Nathalia A. ;
Huber, Peter ;
Bergman, Frank ;
Abdollahi, Amir ;
Friess, Helmut ;
Kleeff, Joerg .
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (06) :1494-1504
[2]   The GDNF family: Signalling, biological functions and therapeutic value [J].
Airaksinen, MS ;
Saarma, M .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (05) :383-394
[3]   Marrow-derived macrophages mediate invasion of pancreatic adenocarcinoma by RET activation [J].
Amit, Moran ;
Na'ara, Shorook ;
Binenbaum, Yoav ;
Gil, Ziv .
CANCER RESEARCH, 2015, 75
[4]   International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck [J].
Amit, Moran ;
Binenbaum, Yoav ;
Trejo-Leider, Leonor ;
Sharma, Kanika ;
Ramer, Naomi ;
Ramer, Ilana ;
Agbetoba, Abib ;
Miles, Brett ;
Yang, Xinjie ;
Lei, Delin ;
Bjorndal, Kristine ;
Godballe, Christian ;
Mucke, Thomas ;
Wolff, Klaus-Dietrich ;
Eckardt, Andre M. ;
Copelli, Chiara ;
Sesenna, Enrico ;
Palmer, Frank ;
Ganly, Ian ;
Patel, Snehal ;
Gil, Ziv .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (07) :1038-1045
[5]  
Ammer Amanda Gatesman, 2009, J Cancer Sci Ther, V1, P52
[6]  
Andres R, 2001, DEVELOPMENT, V128, P3685
[7]   Recent molecular approaches to elucidate the mechanism of embryo implantation: Trophinin, bystin, and tastin as molecules involved in the initial attachment of blastocysts to the uterus in humans [J].
Aoki, R ;
Fukuda, MN .
SEMINARS IN REPRODUCTIVE MEDICINE, 2000, 18 (03) :265-271
[8]   A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment [J].
Apte, Minoti V. ;
Wilson, Jeremy S. ;
Lugea, Aurelia ;
Pandol, Stephen J. .
GASTROENTEROLOGY, 2013, 144 (06) :1210-1219
[9]   Desmoplastic reaction in pancreatic cancer - Role of pancreatic stellate cells [J].
Apte, MV ;
Park, S ;
Phillips, PA ;
Santucci, N ;
Goldstein, D ;
Kumar, RK ;
Ramm, GA ;
Buchler, M ;
Friess, H ;
McCarroll, JA ;
Keogh, G ;
Merrett, N ;
Pirola, R ;
Wilson, JS .
PANCREAS, 2004, 29 (03) :179-187
[10]   Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma [J].
Ayala, GE ;
Dai, H ;
Tahir, SA ;
Li, RL ;
Timme, T ;
Ittmann, M ;
Frolov, A ;
Wheeler, TM ;
Rowley, D ;
Thompson, TC .
CANCER RESEARCH, 2006, 66 (10) :5159-5164