Novel cyanoketene N,S-acetals and pyrazole derivatives using potassium 2-cyanoethylene-1-thiolates

被引：27

作者：

Elgemeie, Galal H. ^{[1
]}

Elghandour, Ahmed H.

Elaziz, Ghada W. Abd

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Bani Suwayf, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 17期

关键词：

activated nitriles; cyanoacetamide; cyano ketene N; S-acetals; cyanothioacetamide; phenylisothiocyanate; pyrazoles;

D O I：

10.1080/00397910701473317

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel ketene N,S-acetals 3 were readily prepared by the reaction of cyanoacetamide or cyanothioacetamide with phenylisothiocyanate in the presence of potassium hydroxide, followed by alkylation of the produced salts with methyl iodide. The reaction of compounds 3 with hydrazines afforded different substituted pyrazoles 6.

引用

页码：2827 / 2834

页数：8

共 3 条

[1] Synthesis of some novel alpha-cyanoketene S,S-acetals and their use in heterocyclic synthesis [J].

Elgemeie, GH ;

Elghandour, AH ;

Elzanate, AM ;

Ahmed, SA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (21) :3285-3289

[2] Novel synthesis of thioguanine and sulfanylpurine analogues: Reaction of heterocyclic ketene dithioacetals with nucleophiles [J].

Elgemeie, GH ;

Elghandour, AH ;

Elzanate, AM ;

Ahmed, SA .

JOURNAL OF CHEMICAL RESEARCH-S, 1998, (03) :162-163

[3]

ELGEMEIE GH, 2001, SYNTHETIC COMMUN, V31, P34853

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