Hypotension after reperfusion in liver transplantation: histidine-tryptophan-ketoglutarate versus University of Wisconsin solution

被引：10

作者：

Ghafaripour, S. ^{[1
]}

Sahmeddini, M. A. ^{[1
]}

Lahsaee, S. M. ^{[1
]}

Khosravi, M. B. ^{[1
]}

Sattari, H. ^{[1
]}

Nikeghbalian, S. ^{[1
]}

Shokrizadeh, S. ^{[1
]}

Malekhosseine, S. A. ^{[1
]}

机构：

[1] Shiraz Med Univ, Shiraz Organ Transplantat Ctr, Shiraz, Iran

来源：

PROGRESS IN TRANSPLANTATION | 2010年 / 20卷 / 03期

关键词：

CLINICAL PANCREAS TRANSPLANTATION; ORGAN PRESERVATION; POSTREPERFUSION SYNDROME; HTK SOLUTION; HEPATIC TRANSPLANTATION; VENTRICULAR-FUNCTION; UW; EXPERIENCE; ALLOGRAFTS; PERFUSION;

D O I：

10.7182/prtr.20.3.18g6j4h7685k0050

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background-The greatest hemodynamic instability during orthotopic liver transplantation occurs at graft reperfusion. Many factors have been implicated. Purpose-To compare hemodynamic changes after reperfusion in grafted livers preserved with histidine-tryptophan-ketoglutarate (HTK) solution versus grafted livers preserved with University of Wisconsin (UW) solution. Methods-In this prospective study, we randomly divided 89 patients who underwent deceased donor liver transplantation into 2 groups: the UW group and the HTK group. The HTK group was further divided into 2 subgroups: flushed and not flushed before reperfusion. The patients were monitored with hemodynamic and metabolic parameters at 3 times: after the skin incision, 5 minutes before reperfusion, and 5 minutes after reperfusion. Results-Hemodynamic parameters in the UW group had not changed significantly at 5 minutes before reperfusion or 5 minutes after reperfusion (P=.45), and the incidence of hypotension after reperfusion in the UW group was 20%. In both HTK groups, the mean arterial pressure 5 minutes after reperfusion was significantly lower than at 5 minutes before reperfusion (P=.002); the incidence of hypotension after reperfusion in the nonflushed HTK group was 83.3% and in the flushed HTK group, 65.5%. Conclusions-The incidence of hypotension after reperfusion is greater if HTK solution rather than UW solution is used. Flushing of grafted livers preserved with HTK solution might eliminate some vasoactive substances found in HTK solution. (Progress in Transplantation. 2010;20:256-261)

引用

页码：256 / 261

页数：6

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