From Structure to Function: the Ecology of Host-Associated Microbial Communities

被引:280
作者
Robinson, Courtney J. [1 ]
Bohannan, Brendan J. M. [3 ]
Young, Vincent B. [1 ,2 ]
机构
[1] Univ Michigan, Dept Internal Med, Div Infect Dis, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
[3] Univ Oregon, Ctr Ecol & Evolutionary Biol, Eugene, OR 97403 USA
关键词
16S RIBOSOMAL-RNA; GRADIENT GEL-ELECTROPHORESIS; INTESTINAL BACTERIAL COMMUNITY; ANTIBIOTIC-ASSOCIATED DIARRHEA; HUMAN COLONIC MICROBIOTA; HUMAN GUT MICROBIOTA; IN-VITRO MODEL; H-2 PLUS CO2; SPECIES RICHNESS; MOLECULAR ANALYSIS;
D O I
10.1128/MMBR.00014-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In the past several years, we have witnessed an increased interest in understanding the structure and function of the indigenous microbiota that inhabits the human body. It is hoped that this will yield novel insight into the role of these complex microbial communities in human health and disease. What is less appreciated is that this recent activity owes a great deal to the pioneering efforts of microbial ecologists who have been studying communities in non-host-associated environments. Interactions between environmental microbiologists and human microbiota researchers have already contributed to advances in our understanding of the human microbiome. We review the work that has led to these recent advances and illustrate some of the possible future directions for continued collaboration between these groups of researchers. We discuss how the application of ecological theory to the human-associated microbiota can lead us past descriptions of community structure and toward an understanding of the functions of the human microbiota. Such an approach may lead to a shift in the prevention and treatment of human diseases that involves conservation or restoration of the normal community structure and function of the host-associated microbiota. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
引用
收藏
页码:453 / +
页数:25
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