Bone Healing After Secondary Surgery on Hand Allografts Under Sirolimus-Based Maintenance Immunosuppression

被引：10

作者：

Cavadas, Pedro C. ^{[2
]}

Hernan, Izaro ^{[1
]}

Landin, Luis ^{[1
,2
]}

Thione, Alessandro ^{[2
]}

机构：

[1] Pedro Cavadas Fdn, Clin Cavadas, Valencia 46021, Spain

[2] Univ Hosp La Fe, Transplant Surg Div, Valencia, Spain

来源：

ANNALS OF PLASTIC SURGERY | 2011年 / 66卷 / 06期

关键词：

composite tissue allograft; hand allograft; sirolimus; bone healing; wound healing; joint arthrodesis; LATE CONVERSION; TRANSPLANTATION; RAPAMYCIN; MTOR;

D O I：

10.1097/SAP.0b013e318212686b

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Composite tissue allograft transplantation is a recognized option for reconstruction in upper limb amputees. Sirolimus is an immunosuppressive drug that prevents organ rejection and improves kidney function, but its use has been associated with impaired healing. Two recipients of bilateral hand allografts underwent arthrodeses of 6 joints as secondary procedures while being treated with sirolimus. We found no clinical or radiologic evidence of bone healing delay or bone nonunion. The functional evaluation revealed an improvement in the performance of activities of daily living after the transplant and secondary procedures. We conclude that bone surgery can be performed safely in recipients of hand allografts who are receiving sirolimus-based immunosuppressive therapy.

引用

页码：667 / 669

页数：3

共 31 条

[1]

Anderson GA, 2005, GREENS OPERATIVE HAN, P1187

[2]

[Anonymous], 2009, AM J TRANSPL S3, V9, pS14

[3] The Innsbruck Hand Transplant Program: Update at 8 Years After the First Transplant [J].

Brandacher, G. ;

Ninkovic, M. ;

Piza-Katzer, H. ;

Gabl, M. ;

Hussl, H. ;

Rieger, M. ;

Schocke, M. ;

Egger, K. ;

Loescher, W. ;

Zelger, B. ;

Ninkovic, M. ;

Bonatti, H. ;

Boesmueller, C. ;

Mark, W. ;

Margreiter, R. ;

Schneeberger, S. .

TRANSPLANTATION PROCEEDINGS, 2009, 41 (02) :491-494

[4] TSC2 regulates VEGF through mTOR-dependent and -independent pathways [J].

Brugarolas, JB ;

Vazquez, F ;

Reddy, A ;

Sellers, WR ;

Kaelin, WG .

CANCER CELL, 2003, 4 (02) :147-158

[5] BILATERAL HAND TRANSPLANTATION: RESULT AT 20 MONTHS [J].

Cavadas, P. C. ;

Landin, L. ;

Ibanez, J. .

JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, 2009, 34E (04) :434-443

[6] Salvage of replanted upper extremities with major soft-tissue complications [J].

Cavadas, Pedro C. .

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2007, 60 (07) :769-775

[7] Temporary catheter perfusion and artery-last sequence of repair in macroreplantations [J].

Cavadas, Pedro C. ;

Landin, Luis ;

Ibanez, Javier .

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2009, 62 (10) :1321-1325

[8] Posttransplantation bone disease [J].

Cunningham, J .

TRANSPLANTATION, 2005, 79 (06) :629-634

[9]

Danovitch GM, 2010, HDB KIDNEY TRANSPLAN, P78

[10]

Doi K, 2001, Brachial plexus injuries, P137

← 1 2 3 4 →