Axonal channelopathies: An evolving concept in the pathogenesis of peripheral nerve disorders

被引：48
作者：
Gutmann, L
Gutmann, L
机构：
[1] Robert C. Byrd Hlth. Sciences Center, West Virginia University, Morgantown, WV
[2] Department of Neurology, Robert C. Byrd Hlth. Sciences Center, West Virginia University, Morgantown
来源：
NEUROLOGY | 1996年 / 47卷 / 01期
关键词：
D O I：
10.1212/WNL.47.1.18
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Abnormalities of peripheral nerve Na+ and K+ channels result in clinical manifestations unrelated to axonal degeneration or demyelination. Na+ channel blockade causes weakness and sensory loss associated with slowed conduction and decreased motor and sensory action potential amplitudes. K+ channel abnormalities result in high frequency repetitive action potentials (e.g., myokymia). Ion channel abnormalities may also play an important role in electrophysiologic changes seen in demyelinating disorders.
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页码：18 / 21
页数：4
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