A Mitochondria-targeted AIEgen Labelled with 18F for Breast Cancer Cell Imaging and Therapy

被引：10
|
作者：
Yu, Kaiwu [1 ]
Zhou, Rui [2 ,3 ]
Xu, Yangyang [1 ]
Zhong, Yan [2 ,3 ]
Qian, Shufang [2 ,3 ]
Zhang, Honghai [2 ,3 ,4 ,5 ]
Shi, Haibin [6 ]
He, Qinggang [1 ,7 ]
Mao, Zhengwei [8 ]
Zhang, Haoke [8 ]
Wei, Yen [9 ,10 ]
Zhang, Hong
Tian, Mei [2 ,3 ]
机构：
[1] Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Hosp 2, Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Hosp 2, PET CT Ctr, Hangzhou 310009, Zhejiang, Peoples R China
[4] Nanjing Tech Univ, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, Key Lab Flexible Elect KLOFE, Nanjing 211816, Jiangsu, Peoples R China
[5] Nanjing Tech Univ, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Nanjing 211816, Jiangsu, Peoples R China
[6] Soochow Univ, Sch Radiol & interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, State Key Lab Radiat Med & Protect,Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China
[7] Zhejiang Univ, Ningbo Res Inst, Ningbo 315100, Zhejiang, Peoples R China
[8] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromolecular Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[9] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
[10] Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2021年 / 16卷 / 23期
基金：
中国国家自然科学基金;
关键词：
aggregation-induced emission; positron emission tomography; imaging and therapy; mitochondria; breast cancer; EMISSION;
D O I：
10.1002/asia.202101029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A lack of efficient diagnostic tools for early and noninvasive diagnosis of breast cancer has restricted the clinical treatment effect. This problem might be addressed by the combination of aggregation-induced emission (AIE) fluorescence imaging and positron emission tomography (PET) with the dual advantages of high resolution and easy operation, and unlimited penetration and high sensitivity. Here, a mitochondria-targeted AIE luminogen (AIEgen) radiolabeled with F-18 was developed through a two-step radiochemical reaction by virtue of a prosthetic group. The obtained F-18/19-Bz-CP imaging probe was examined by in vitro cell uptake and cell proliferation inhibition in two breast cancer cell lines, showing that the probe can efficiently target and locate in the mitochondria through the analysis of fluorescence imaging and PET simultaneously. Additionally, the probe can induce cancer cell apoptosis with the half maximal inhibitory concentration (IC50) of 4.8 mu M for MCF-7 cells and 7.2 mu M for T47D cells, indicating its potential application for breast cancer therapy.
引用
收藏
页码：3963 / 3969
页数：7
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