Drug-Induced Hypoglycaemia An Update

被引:48
作者
Ben Salem, Chaker [1 ]
Fathallah, Neila [1 ]
Hmouda, Houssem [2 ]
Bouraoui, Kamel [1 ]
机构
[1] Fac Med Sousse, Dept Clin Pharmacol, Sousse, Tunisia
[2] Sahloul Univ Hosp, Med Intens Care Unit, Sousse, Tunisia
关键词
TYPE-2; DIABETES-MELLITUS; SUBCUTANEOUS INSULIN INFUSION; DISOPYRAMIDE-INDUCED HYPOGLYCEMIA; ORAL ANTIDIABETIC AGENTS; DOUBLE-BLIND TRIAL; GLYCEMIC CONTROL; GLUCOSE-HOMEOSTASIS; TRIMETHOPRIM-SULFAMETHOXAZOLE; SYMPTOMATIC HYPOGLYCEMIA; PLASMA-CONCENTRATIONS;
D O I
10.2165/11538290-000000000-00000
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Drugs are the most frequent cause of hypoglycaemia in adults. Although hypoglycaemia is a well known adverse effect of antidiabetic agents, it may occasionally develop in the course of treatment with drugs used in everyday clinical practice, including NSAIDs, analgesics, antibacterials, antimalarials, antiarrhythmics, antidepressants and other miscellaneous agents. They induce hypoglycaemia by stimulating insulin release, reducing insulin clearance or interfering with glucose metabolism. Several drugs may also potentiate the hypoglycaemic effect of antidiabetic agents. Administration of these agents to individuals with diabetes mellitus is of most concern. Many of these drugs, and depending on clinical setting, may also induce hyperglycaemia. Drug-induced hepatotoxicity and nephrotoxicity may lead in certain circumstances to hypoglycaemia. Some drugs may also induce hypoglycaemia by causing pancreatitis. Drug-induced hypoglycaemia is usually mild but may be severe. Effective clinical management can be handled through awareness of this drug-induced adverse effect on blood glucose levels. Herein, we review pertinent clinical information on the incidence of drug-induced hypoglycaemia and discuss the underlying pathophysiological mechanisms, and prevention and management.
引用
收藏
页码:21 / 45
页数:25
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