Raman spectroscopy for the process analysis of the manufacturing of a suspension metered dose inhaler

被引：12
作者：
Butz, James [1 ]
de la Cruz, Luis [1 ]
DiTonno, Jason [1 ]
DeBoyace, Kevin [1 ]
Ewing, Gary [1 ]
Donovan, Brent [1 ]
Medendorp, Joseph [1 ]
机构：
[1] Merck Resp Prod Dev, Summit, NJ 07901 USA
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2011年 / 54卷 / 05期
关键词：
Raman spectroscopy; Respiratory; Process analytical technology; Process control; PAT; IN-LINE; PAT TOOL;
D O I：
10.1016/j.jpba.2010.12.007
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The purpose of this research was to demonstrate the utility of Raman spectroscopy for process analysis of a suspension metered dose inhaler manufacturing process. Chemometric models were constructed for the quantification of ethanol and active pharmaceutical ingredient such that both could be monitored in real-time during the compounding and filling operations via tank measurements and recirculation line flow-cell measurements. Different spectral preprocessing techniques were used to delineate the effects of mixing speed and temperature changes from actual concentration effects. Raman spectroscopy offers advantages in time savings and quality of information over the standard methods of analysis for respiratory formulations, such as a drug content assay via HPLC and ethanol testing via GC. The successful implementation of this work will allow formulation scientists to quantitatively assess both the formulation (e.g., the concentration of active pharmaceutical ingredient (API) and ethanol), as well as the manufacturing process (e.g., determination of mixing endpoints) in real-time. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1013 / 1019
页数：7
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