The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism

被引：59

作者：

Szanto, Magdolna ^{[1
]}

Bai, Peter ^{[1
,2
,3
]}

机构：

[1] Univ Debrecen, Fac Med, Dept Med Chem, H-4032 Debrecen, Hungary

[2] Univ Debrecen, MTA DE Lendulet Lab Cellular Metab, H-4032 Debrecen, Hungary

[3] Univ Debrecen, Fac Med, Res Ctr Mol Med, H-4032 Debrecen, Hungary

来源：

GENES & DEVELOPMENT | 2020年 / 34卷 / 5-6期

关键词：

PARP; ARTD; adipocyte; adipogenesis; mitochondria; lipolysis; differentiation; white adipocytes; brown adipocytes; beige adipocytes; stem cell; PARylation; high fat diet; obesity; insulin resistance; AFLD; NAFLD; atherosclerosis; POLY(ADP-RIBOSE) POLYMERASE 1; HIGH-FAT DIET; NF-KAPPA-B; E-DEFICIENT MICE; DNA-REPAIR; PARP-1; DEFICIENCY; GENE-EXPRESSION; PPAR-GAMMA; CELL-DEATH; PHARMACOLOGICAL INHIBITION;

D O I：

10.1101/gad.334284.119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating adipocyte function and organismal energy balance, PARPs play a role in obesity and the consequences of obesity. These findings can be translated into humans, as evidenced by studies on identical twins and SNPs affecting PARP activity.

引用

页码：321 / 340

页数：20

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