Cancer metabolomics in basic science perspective

被引:27
作者
Kwon, Hyuknam [1 ]
Oh, Sehyun [1 ]
Jin, Xing [1 ]
An, Yong Jin [1 ]
Park, Sunghyouk [1 ]
机构
[1] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 151742, South Korea
基金
新加坡国家研究基金会;
关键词
Metabolomics; Cancer metabolism; Metabolic enzymes; SPECTROMETRY-BASED METABOLOMICS; GLUTAMINE-METABOLISM; TUMOR-CELLS; MASS-SPECTROMETRY; REDUCTIVE CARBOXYLATION; ALPHA-KETOGLUTARATE; IDH2; MUTATIONS; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; MITOCHONDRIAL METABOLISM; BIOMARKER DISCOVERY;
D O I
10.1007/s12272-015-0552-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
As metabolomics investigates metabolic pathways with the focus on metabolites, it is a suitable approach to address the complex metabolic alteration in cancer. In addition, metabolic profiles are affected by environmental and post-natal changes, and therefore, directly measuring many metabolites may provide epigenetically relevant information in cancer. Despite much development in our understanding of cancer metabolism, focus is often directed to signaling or metabolic proteins that modulate the metabolite levels. In this review, we discuss the "metabolite-oriented view'' on cancer metabolism. We cover how metabolomics research contributed to our current insights into the basic mechanism of metabolic alterations leading to cancer. Then, we discuss specific metabolites and related enzymatic pathways directly related with tumorigenesis. We particularly pay attention to how metabolites regulate signaling proteins and metabolic enzymes ultimately leading to cancer phenotypes. Finally, we address future prospects and challenges of metabolomics in cancer research.
引用
收藏
页码:372 / 380
页数:9
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