Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity

被引：12

作者：

Gerlini, R. ^{[1
,2
]}

Berti, L. ^{[2
,3
]}

Darr, J. ^{[1
,2
]}

Lassi, M. ^{[1
,2
]}

Brandmaier, S. ^{[2
]}

Fritsche, L. ^{[2
,3
]}

Scheid, F. ^{[1
,2
]}

Boehm, A. ^{[2
,3
,4
]}

Koenigsrainer, A. ^{[7
]}

Grallert, H. ^{[2
,8
,9
]}

Haering, H. U. ^{[2
,3
,4
]}

de Angelis, M. Hrabe ^{[1
,2
,6
]}

Staiger, H. ^{[2
,3
,5
]}

Teperino, R. ^{[1
,2
]}

机构：

[1] German Res Ctr Environm Hlth Neuherberg, Inst Expt Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany

[2] German Ctr Diabet Res DZD Neuherberg, Oberschleissheim, Germany

[3] Eberhard Karls Univ Tubingen, Inst Diabet Res & Metab Dis, Helmholtz Ctr Munich, Tubingen, Germany

[4] Univ Tubingen, Dept Internal Med 4, Div Endocrinol Diabetol Angiol Nephrol & Clin Che, Tubingen, Germany

[5] Univ Tubingen, Inst Pharmaceut Sci, Dept Biochem & Pharm, Tubingen, Germany

[6] Tech Univ Munich, Expt Genet, Fac Life & Food Sci Weihenstephan, Freising Weihenstephan, Germany

[7] Univ Tubingen, Dept Gen Visceral & Transplant Surg, Tubingen, Germany

[8] German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany

[9] German Res Ctr Environm Hlth, Inst Epidemiol 2, Helmholtz Zentrum Munchen, Neuherberg, Germany

来源：

MOLECULAR METABOLISM | 2018年 / 18卷

关键词：

Obesity; Glucose tolerance; Insulin sensitivity; Transcriptomics; Mouse genetics; Systemic phenotyping; POLYCOMB PROTEIN; GENE-EXPRESSION; ADIPOSE-TISSUE; DISEASE; CONSORTIUM; PATHWAY; LEPTIN;

D O I：

10.1016/j.molmet.2018.09.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Although debated, metabolic health characterizes 10-25% of obese individuals and reduces risk of developing life-threatening comorbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown. Methods: Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases. Results and conclusions: Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity. (C) 2018 The Authors. Published by Elsevier GmbH.

引用

页码：42 / 50

页数：9

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