Ritter-type reactions of N-chlorosaccharin:: A method for the electrophilic diamination of alkenes

被引：46
作者：
Booker-Milburn, KI
Guly, DJ
Cox, B
Procopiou, PA
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 18期
关键词：
D O I：
10.1021/ol035374m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] N-Chlorosaccharin has been shown to undergo electrophilic Ritter-type reactions with alkenes in acetonitrile. The resulting labile beta-chloro sulfonylamidines can be ring-opened and cyclized to imidazolines. Overall this provides a one pot method for the electrophilic diamination of alkenes. Competing aziridine formation as well as allylic chlorination are also observed depending on the nature of the alkene used.
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页码：3313 / 3315
页数：3
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