Design, Synthesis, and Application of Polymer-Supported Silicon-Transfer Agents for Cross-Coupling Reactions with Organolithium Reagents

被引：11

作者：

Nguyen, Minh H.

O'Brien, Kevin T.

Smith, Amos B., III ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Res Struct Matter Lab, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 20期

关键词：

C-SP2-TO-O SILYL MIGRATION; NICKEL-CATALYZED REACTION; SILOXANE TRANSFER AGENTS; STEREOSPECIFIC ALLYLATION; STEREOSELECTIVE-SYNTHESIS; POLYSTYRENE RESINS; GRIGNARD-REAGENTS; ROOM-TEMPERATURE; GENERAL-SOLUTION; BORONIC ACIDS;

D O I：

10.1021/acs.joc.7b02004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The initial design, synthesis, and validation of polymer supported siloxane transfer agents have been achieved that permit the direct use of organolithium reagents in the palladium-catalyzed cross coupling reactions. Through rational design, two generations of polymer support were developed that significantly simplify product purification and the transfer agent recycling.

引用

收藏

页码：11056 / 11071

页数：16

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